what does nmn stand for?

 

NMN, or Nicotinamide Mononucleotide, is the direct precursor of nicotinamide adenine dinucleotide (NAD+). NAD+ is an important coenzyme in cells that participates in many key physiological and metabolic reactions in the body. NMN generates NAD+ through a series of enzymatic reactions in cells, and plays a vital role in maintaining cellular energy metabolism, DNA repair, cell aging, and nervous system health.

What does NMN do?

The effects of NMN are mainly related to its conversion into NAD+ in cells. With age or in certain disease states, NAD+ levels decrease, leading to a decline in cell function. Supplementing with NMN can increase NAD+ levels in cells, which can help improve a variety of physiological problems associated with aging. Studies have shown that NMN can improve metabolic health, enhance DNA repair, promote cellular energy metabolism, improve cognitive function, protect nerve cells, reduce oxidative stress, regulate immune function, and may even help prolong life. In addition, NMN has shown potential in improving skin health, improving vision, improving hearing, and reducing age-related physical dysfunction.

Currently, there are multiple scientific studies supporting the health benefits of NMN (nicotinamide mononucleotide). Here are some key research areas and findings:

1. Anti-aging effect: As a direct precursor of NAD+, NMN can increase intracellular NAD+ levels, thereby slowing down age-related physiological decline. Studies have shown that NMN can improve a variety of aging-related symptoms in elderly mice, including improving energy metabolism, muscle function, and cognitive ability.

2. Metabolic regulation: NMN can improve insulin sensitivity by increasing NAD+ levels, and has the potential to improve metabolic diseases such as type 2 diabetes and obesity.

3. Neuroprotection: NMN helps protect nerve cells and reduce the risk of neurodegenerative diseases. It can improve cognitive function, and its potential therapeutic effects on diseases such as Alzheimer's disease and Parkinson's disease are being studied.

4. Muscle health: Supplementing with NMN can improve muscle strength and performance, and has a positive impact on the elderly and athletic performance.

6. Skin health: NMN helps protect the skin from external factors such as UV rays and may help reduce signs of skin aging.

7. Immune function: NMN has a positive effect on the function of immune cells and may help enhance the body's immune response.

8. DNA repair: NMN helps enhance DNA repair and reduce cell damage by increasing NAD+ levels.

How much NMN is healthy to take?

There is no uniform standard regarding the dosage of NMN, as the required dosage may vary depending on individual differences, age, health status, and desired effects. According to existing clinical studies, the dosage ranges from tens of milligrams to thousands of milligrams per day. For example, the dosage used in some studies is 250 mg per day, while other studies may use doses as high as 1000 mg per day. It is important that NMN supplementation should be carried out under the guidance of a doctor or health professional to ensure safety and effectiveness. The safety of long-term high-dose use of NMN needs further research to confirm.

In addition, the bioavailability and effect of NMN may be affected by factors such as the time of intake, interaction with other nutrients, and individual differences. Therefore, it is recommended to consult a medical professional before starting any supplementation program and to personalize it to one’s individual health status and needs.

References:

[1] Yamaguchi S, Irie J, Mitsuishi M, Uchino Y, Nakaya H, Takemura R, Inagaki E, Kosugi S, Okano H, Yasui M, Tsubota K, Hayashi K, Yoshino J, Itoh H. Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men. Endocr J. 2024 Feb 28;71(2):153-169. doi: 10.1507/endocrj.EJ23-0431. Epub 2024 Jan 6. PMID: 38191197.

[2] Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. Adv Nutr. 2023 Nov;14(6):1416-1435. doi: 10.1016/j.advnut.2023.08.008. Epub 2023 Aug 22. PMID: 37619764; PMCID: PMC10721522.

[3] Zheng C, Li Y, Wu X, Gao L, Chen X. Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide. Nutrients. 2024 Jul 20;16(14):2354. doi: 10.3390/nu16142354. PMID: 39064797; PMCID: PMC11279976.

[4] Lee, Y.J.; Jang, S.G.; Ryu, M.J.; Choi, S.H. Nicotinamide Riboside Ameliorates Hyperpigmentation on Photo-Irradiated Skin. Cosmetics 2024, 11, 73. https://doi.org/10.3390/cosmetics11030073

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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