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Glutathione, as a powerful antioxidant, has received widespread attention in the field of skin whitening in recent years. It occurs naturally in the human body and plays a key role in cellular health and detoxification processes.
Glutathione is thought to affect skin pigmentation through a variety of mechanisms. First, it may inhibit the activity of tyrosinase, a key rate-limiting enzyme in melanin synthesis. Secondly, glutathione can affect the type of melanin, converting darker eumelanin into lighter pheomelanin. Additionally, glutathione’s antioxidant properties help neutralize free radicals and reduce oxidative stress, which may help manage skin pigment issues.
Research shows that a combination of topical and oral glutathione may be superior to glutathione alone. The double-blind randomized controlled clinical trial involving 46 participants showed that the combination group showed significantly lower melanin index (MI) and higher L* score (skin lightness) after 8 weeks compared with the placebo group There is a significant difference. This suggests that glutathione may have some potential in skin whitening.
As a naturally occurring substance in the body, topical and oral forms of glutathione are generally considered to have a lower risk of side effects. However, like any other whitening product, individual reactions may vary, so it is important to seek the advice of a dermatologist or medical professional before use.
Future studies may explore different formulations and routes of administration of glutathione to achieve more effective and safe whitening results.
As an emerging whitening ingredient, glutathione, with its unique mechanism of action and the support of clinical research, provides a new choice for those who pursue skin whitening. However, when using any whitening product, safety always comes first. Therefore, before using glutathione products, it is recommended to consult a professional and pay close attention to any possible side effects. As scientific research continues to deepen, we have reason to believe that glutathione will play a greater role in the field of whitening.
[1] Wahab S, Anwar A I, Zainuddin A N, et al. Combination of topical and oral glutathione as a skin-whitening agent: a double-blind randomized controlled clinical trial[J]. International Journal of Dermatology, 2021, 60(8 ): 1013-1018.
[2] Karunarathna I, Bandara S, Jayawardana A, et al. From Theory to Practice: The Efficacy and Safety of Glutathione-Based Skin Lightening Agents[J].
[3] Li B, Mei H, Zhou Z, et al. The main causes and corresponding solutions of skin pigmentation in the body[J]. Journal of Dermatologic Science and Cosmetic Technology, 2024, 1(2): 100020.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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