Why is glutathione a highly anticipated cosmetic ingredient?

 

Glutathione (GSH), as a tripeptide molecule with antioxidant properties and the ability to regulate melanin production, has always received widespread attention in the cosmetics field. Its application potential in whitening, anti-oxidation and improving skin texture makes it a highly anticipated ingredient.

1. Whitening mechanism of glutathione

The mechanism of action of glutathione in skin whitening is mainly based on its regulation of the melanin production process. Melanin is the main determinant of skin color, and glutathione reduces melanin production by inhibiting the activity of tyrosinase. Tyrosinase is a key enzyme in the synthesis of melanin. Glutathione can bind to the copper ions in the active center of tyrosinase, thereby inhibiting its catalytic effect, reducing the production of eumelanin, and promoting the conversion to light-colored pheomelanin. In addition, glutathione also reduces oxidative stress through antioxidant effects, further reducing the production of melanin.

2. Application forms of glutathione in cosmetics

Oral glutathione supplements

Oral glutathione supplements are a whitening method that has attracted much attention in recent years. Studies have shown that oral glutathione can significantly reduce the level of melanin in the skin, especially in sun-exposed areas. For example, a randomized double-blind placebo-controlled trial found that after four weeks of daily supplementation with 500 mg of glutathione, the melanin index of the subjects decreased significantly. However, the effect of oral glutathione is affected by dose, treatment cycle and individual differences, and some studies have failed to observe significant whitening effects. In addition, oral glutathione has low absorption efficiency and limited bioavailability, which limits its widespread application in cosmetics.

Topical glutathione preparations

Topical glutathione preparations perform well in whitening and improving skin texture. Studies have shown that 2% glutathione lotion can significantly reduce the melanin index and improve skin moisture retention and texture after 10 weeks of continuous use. In addition, topical glutathione has also shown good results in the treatment of pigmentation diseases such as melasma, which can significantly reduce the melasma area severity index (mMASI) and improve the quality of life of patients. Topical glutathione is relatively safe and usually does not cause serious adverse reactions.

Combined use of glutathione with other ingredients

In order to improve the whitening effect of glutathione, many cosmetics use it in combination with other ingredients. For example, the combination of glutathione with antioxidants such as vitamin C and α-lipoic acid can enhance its antioxidant and whitening effects. In addition, the combined use of glutathione with ingredients such as fruit acid and retinol also shows good synergistic effects, which can further improve the overall condition of the skin.

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*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

GSHWORLD is China Biological API Manufacturer. China Glutathione Supplements powder suppliers & best Glutathione benefits raw material Factory.