Why is NMN a Hotspot in Anti-Aging Research?

 

β-Nicotinamide Mononucleotide(NMN) is a precursor of nicotinamide adenine dinucleotide (NAD⁺), which plays a key role in cellular energy metabolism, DNA repair, and various cellular stress responses. In recent years, the relationship between NMN and longevity has become a research hotspot in the field of aging biology.

1. The Role of NMN in NAD⁺ Metabolism

NAD⁺ is a cofactor for many important enzymes within cells, participating in cellular energy metabolism and signal transduction. However, with increasing age, the levels of NAD⁺ in the body significantly decline, and this decline is considered a key driving factor of aging. As the direct precursor of NAD⁺, NMN can effectively replenish the levels of NAD⁺ in the body. Studies have shown that NMN is rapidly absorbed and utilized in mice, and can significantly increase the concentration of NAD⁺ in blood and tissues within a short period of time. This rapid replenishment mechanism makes NMN a potential anti-aging intervention.

2. The Impact of NMN on Mitochondrial Function

Mitochondria are the powerhouses of the cell, and maintaining their function is crucial for cellular health. With increasing age, mitochondrial function gradually deteriorates, leading to reduced energy metabolism efficiency and triggering various aging-related diseases. By increasing NAD⁺ levels, NMN can improve mitochondrial function. Research has found that NMN can restore the oxidative phosphorylation activity of mitochondria in aged mice, increase ATP production, and thereby improve the cellular energy state. In addition, NMN can also regulate mitochondrial biogenesis and function by activating NAD⁺-dependent deacetylases such as SIRT1, further delaying aging.

3. The Ameliorative Effects of NMN on Aging-Related Diseases

In addition to improving mitochondrial function, NMN has been proven to ameliorate a variety of aging-related diseases. For example, in diet-induced obese mouse models, NMN can significantly improve insulin resistance and restore normal blood glucose levels. In aged mice, NMN supplementation can enhance muscle function, increase muscle strength and endurance, and delay muscle aging. Moreover, NMN can also improve cognitive function, reduce neuroinflammation, and potentially prevent neurodegenerative diseases such as Alzheimer's disease.

As a precursor of NAD⁺, NMN shows great potential in delaying aging and extending lifespan. It provides new hope for healthy longevity by improving mitochondrial function, regulating metabolic processes, and alleviating aging-related diseases. NMN has demonstrated significant anti-aging effects in animal experiments, and with further research, it is expected to become one of the important means of anti-aging therapy in the future.

References:

Imai, Si. NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control. npj Aging 11, 4 (2025). https://doi.org/10.1038/s41514-025-00192-6

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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