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As an important detoxification organ of the human body, the liver plays an indispensable role in maintaining physical health. However, in modern society, due to bad living habits, environmental pollution and the influence of various diseases, the health of the liver faces many challenges. Therefore, finding effective raw materials that can nourish the liver and remove toxins has become the focus of people's attention.
Glutathione (GSH) is an important antioxidant that is widely present in human cells and plays an important role in maintaining intracellular redox balance and protecting cells from oxidative damage. Glutathione can bind to a variety of toxins and promote their excretion from the body, thereby reducing the detoxification burden of the liver. In addition, glutathione is also involved in a variety of biochemical reactions, such as reactions catalyzed by glutathione-S-transferase (GST), which helps to remove harmful substances in the body.
Nicotinamide mononucleotide (NMN) is an important NAD+ precursor substance. In recent years, research on anti-aging and liver protection has attracted widespread attention. Studies have shown that NMN supplementation can promote liver growth, and its mechanism is closely related to regulating transcription and metabolism. In a study of immunodeficient mice, researchers found that oral administration of NMN significantly increased liver weight and increased the expression levels of proteins such as growth hormone receptor (GHR), insulin-like growth factor 1 (IGF-1), SIRT1, YAP1, JAK1, and STAT3. These proteins play an important role in cell proliferation, metabolic regulation, and gene expression. In addition, NMN can improve amino acid metabolism and provide an important material basis for liver growth.
In another study, researchers evaluated the effects of NMN on muscle and liver function in middle-aged and elderly people. The results showed that NMN supplementation can significantly improve muscle function, reduce insulin resistance, and reduce liver aminotransferase levels. These results show that NMN not only promotes liver growth, but also improves liver function and reduces risk factors associated with liver disease.
S-adenosylmethionine (SAMe) is a natural compound with significant potential in liver health. A systematic review of the use of SAMe in liver disease showed that SAMe can effectively improve liver-related parameters with few adverse reactions, mainly mild gastrointestinal discomfort. In multiple studies, SAMe has been shown to significantly reduce the levels of liver function indicators (such as AST, ALT, LDH, TBil, GGT, and ALP), improve liver fat content and liver morphology.
The mechanism of action of SAMe may be related to its characteristics as a methyl donor. It participates in a variety of biochemical reactions, including the synthesis of glutathione, thereby exerting an antioxidant effect. In addition, SAMe can also regulate cell signaling pathways, promote cell proliferation and tissue repair. Therefore, SAMe can be used as a safe and effective liver protector, especially for patients with chronic liver disease.
Raw materials such as glutathione (GSH), nicotinamide mononucleotide (NMN), and S-adenosylmethionine (SAMe) have certain potential in liver health. NMN promotes liver growth and functional improvement by regulating transcription and metabolism; SAMe, as a methyl donor, participates in various biochemical reactions and improves liver function indicators; glutathione protects the liver from oxidative damage and toxins through its antioxidant and detoxification functions.
However, it should be noted that the supplementation effect of these raw materials may be affected by many factors, such as dosage, supplementation time, individual differences, etc. Therefore, when using these raw materials for liver protection, they should be reasonably selected according to the specific situation and carried out under the guidance of professional doctors. At the same time, maintaining a healthy lifestyle, such as a reasonable diet, moderate exercise, and avoiding excessive drinking, is also an important measure to maintain liver health.
[1] Mangkalopakorn P, Segsarnviriya C, Keeratipranon M, et al. Glutathione Levels after Glutathione Supplementation: A Systematic Review and Meta-analysis[J]. Journal of Current Science and Technology, 2025, 15(1): 90-90.
[2] Su M, Wang J, Yuan Y, et al. NMN supplementation promotes liver growth-The result of the regulated transcription and metabolism[J]. 2023.
[3] Wang J, Wang L, Wang T, et al. Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-Aged and Elderly: A Systematic Review and Meta-Analysis of Randomized Controlled Trials[J]. Current pharmaceutical biotechnology, 2024.
[4] Baden K E R, McClain H, Craig E, et al. S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review[J]. Nutrients, 2024, 16(21): 3668.
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