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Nicotinamide adenine dinucleotide (NAD) is a key coenzyme that plays an important role in cellular metabolism and energy production.
As we age, NAD levels in the human body gradually decrease, and this change is closely related to the decline of cellular function and the aging process.
NAD is involved in a variety of biological processes in cells, including DNA repair and the maintenance of mitochondrial function.
By supplementing NAD precursors, such as nicotinamide riboside (NR) and Nicotinamide Mononucleotide (NMN), NAD levels in the body can be effectively increased, thereby activating the activity of deacetylases such as SIRT1.
These enzymes play an important role in regulating gene expression and promoting cellular antioxidant capacity, helping to delay the cellular aging process and maintain cell vitality and function. In addition, NAD supplementation can also improve mitochondrial function and enhance cellular energy metabolism, thereby delaying the aging process of the body as a whole.
NAD plays an important role in energy metabolism, and changes in its levels are closely related to metabolic health.
Supplementing NAD precursors can increase the body's NAD levels, improve insulin sensitivity, and promote fat and sugar metabolism. This has positive significance for maintaining a healthy weight and blood sugar level.
In addition, NAD is also involved in the β-oxidation process of fatty acids.
Supplementing NAD helps increase fat consumption and has potential health care effects on weight loss and improving obesity-related metabolic disorders.
By regulating NAD levels, a healthy metabolic state can be promoted and the occurrence of metabolic diseases can be prevented.
NAD plays an important protective role in the nervous system.
The deacetylase SIRT1 in which it participates can regulate the survival and function of neurons and protect neurons from oxidative stress and inflammatory damage.
In addition, NAD is also involved in the mitochondrial autophagy process, helping to remove damaged mitochondria and maintain the normal function of neurons.
By supplementing NAD precursors, the NAD level in neurons can be increased, protective signaling pathways such as SIRT1 can be activated, mitochondrial autophagy can be promoted, and neuronal damage can be reduced, thereby having a positive health care effect on the health of the nervous system.
This is of great significance for preventing cognitive decline and maintaining good neurological health.
NAD's important role in energy metabolism makes it potentially valuable for improving athletic performance.
During exercise, muscle cells require a lot of energy to support muscle contraction and motor activity.
NAD helps cells use oxygen and nutrients more efficiently by participating in the energy metabolism process of mitochondria, thereby improving the efficiency of energy production and utilization.
Supplementing NAD precursors can increase NAD levels in muscle cells, improve muscle energy metabolism, enhance muscle endurance and strength, and improve athletic performance.
This has positive health benefits for people who want to improve their athletic ability and physical fitness.
In summary, NAD has many potential roles in the health care field. It has broad application prospects in delaying aging, improving metabolic health, promoting neurological health, and improving athletic performance.
Reasonable supplementation of NAD precursors can provide important support and protection for human health.
However, more scientific research is still needed to clarify the specific mechanism, optimal dose, and long-term effects of NAD supplementation to ensure its safety and effectiveness in health care applications.
[1] Chini C C S, Cordeiro H S, Tran N L K, et al. NAD metabolism: Role in senescence regulation and aging[J]. Aging cell, 2024, 23(1): e13920.
[2] Lautrup S, Hou Y, Fang E F, et al. Roles of NAD+ in Health and Aging[J]. Cold Spring Harbor Perspectives in Medicine, 2024, 14(1): a041193.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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