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In recent years, as research on the mechanisms of aging continues to deepen, Nicotinamide Mononucleotide (NMN), as an important precursor of the coenzyme NAD+, has received widespread attention. NAD+ is involved in many key cellular processes in the human body, including energy metabolism, DNA repair, and cell signaling. As we age, NAD+ levels naturally decline, and increasing NAD+ levels by supplementing NMN is considered to have significant potential for improving human health.
The decline of muscle function is a common phenomenon in the aging process, which not only affects the quality of life of the elderly, but also may lead to a variety of health problems. Studies have shown that NMN supplements can significantly improve muscle function. For example, in a systematic review and meta-analysis, researchers found that NMN had a significant effect on muscle mass in middle-aged and elderly people, and NMN showed its positive effect on muscle function by increasing walking speed, an important indicator. In addition, NMN also improves insulin resistance, which may be closely related to the improvement of muscle function, because muscle is one of the main target tissues of insulin action. In another study, NMN supplements were also found to improve grip strength, and although the improvement was not statistically significant, the trend still suggests that NMN may have a potential positive effect on muscle strength.
The liver is an important metabolic organ in the human body. As we age, liver function gradually declines, resulting in a weakened ability to metabolize drugs and toxins, increasing the risk of liver damage. NMN supplements have also shown some potential in improving liver function. Studies have found that NMN can significantly reduce the level of alanine aminotransferase (ALT) in serum, suggesting that NMN may help reduce liver damage and inflammation. In addition, NMN may also protect the liver from oxidative stress by enhancing the liver's antioxidant capacity. In animal models, NMN has been shown to reduce the occurrence of liver fibrosis and fatty liver, which is of great significance for the prevention and treatment of age-related liver diseases.
Cardiovascular disease is one of the leading causes of death worldwide, and the incidence of cardiovascular disease increases significantly with age. NMN supplements have also shown some protective effects on cardiovascular health. Studies have shown that NMN can improve endothelial function and reduce arterial stiffness, which is of great significance for preventing the occurrence of cardiovascular disease. In addition, NMN may also enhance cardiac tolerance and function by improving the antioxidant capacity and energy metabolism of the heart. In animal models, NMN has been shown to reduce myocardial ischemia-reperfusion injury, which has potential clinical value for improving the prognosis of cardiovascular disease.
The decline of cognitive function is one of the common phenomena in the aging process, which seriously affects the quality of life of the elderly. Studies have shown that NMN supplements may have certain potential for improving cognitive function. In animal models, NMN has been shown to improve learning and memory ability and reduce neuroinflammation and oxidative stress. In addition, NMN may also protect nerve cells from damage by enhancing mitochondrial function and energy metabolism. Although there are relatively few studies on the effects of NMN on human cognitive function, these preliminary research results suggest that NMN may have potential clinical value for preventing and treating age-related cognitive decline.
In summary, NMN supplements have shown certain potential in improving human health, including improving muscle function, protecting liver function, promoting cardiovascular health, and improving cognitive function. However, current research is still in its early stages, and further research is needed to clarify issues such as the optimal dose of NMN supplements, long-term safety, and individualized effects on different populations. Future research should focus on exploring the mechanism of action of NMN supplements, optimizing their dose and dosing regimen, and conducting larger-scale clinical trials to fully evaluate the potential and safety of NMN supplements in improving human health.
[1] Wen J, Syed B, Kim S, et al. Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials[J]. Cureus, 2024, 16(8).
[2] Benjamin C, Crews R. Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications[J]. Metabolites, 2024, 14(6): 341.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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