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Citicoline, also known as CDP-choline, is a natural metabolite found in all living cells and has been used as a medicine since the 1980s and in recent years has been recognized as a food Element. It is broken down into cytosine and choline in the human body, which enter their respective normal metabolic pathways.
Choline is the precursor of acetylcholine, a key neurotransmitter essential for learning and memory and an important component of neuronal membranes and myelin sheaths.
Cytosine is easily converted into uridine in the human body, which has a positive impact on synaptic function and supports the formation of synaptic membranes.
Research has shown that choline deficiency is associated with memory dysfunction, and magnetic resonance spectroscopy studies have shown that citicoline intake can increase choline uptake in the brains of older adults, suggesting that it may help reverse age-related cognitive changes.
The benefits of Citicoline supplementation are primarily seen in its positive effects on cognitive function and behavior. Clinical trials have shown that citicoline can significantly improve cognitive function and memory. Especially in middle-aged and older adults, citicoline has shown positive memory benefits.
Although citicoline has shown positive effects in many studies, there is no clear indication of which groups should not take citicoline. However, in general, as with any supplement, especially people with special health conditions or who are taking other medications, they should seek the advice of a doctor or professional before taking it.
Citicoline may be particularly beneficial for middle-aged and older adults who experience age-related memory impairment, including those without overt neurological or psychiatric disease. In addition, citicoline may also help improve memory and other cognitive functions in people with certain chronic neurological conditions, such as those with mild cognitive impairment or Parkinson's disease.
Citicoline’s benefits extend beyond improving memory function. It may also contribute to neuroprotection by promoting phospholipid synthesis and nerve repair, as well as inhibiting apoptosis associated with neurodegenerative diseases. Research suggests that citicoline may also have benefits for visual function, particularly in improving glaucoma.
Citicoline supplements have gained attention for their potential neuroprotective and cognitive-enhancing effects. However, despite the positive findings, more high-quality studies are needed to verify its long-term effects and safety. Additionally, people with special health needs should consider using citicoline supplements under the guidance of a physician.
[1] Tosefsky K N, Zhu J, Wang Y N, et al. The Role of Diet in Parkinson’s Disease[J]. Journal of Parkinson’s Disease, 2024 (Preprint): 1-14.
[2] Hersant H, He S, Maliha P, et al. Over the counter supplements for memory: a review of available evidence[J]. CNS drugs, 2023, 37(9): 797-817.
[3] Nakazaki E, Lili L, Zhang B, et al. Investigating Specific Molecular and Functional Impacts of Citicoline on Brain Health[J]. Current Developments in Nutrition, 2024, 8.
[4] Bonvicini M, Travaglini S, Lelli D, et al. Is citicoline effective in preventing and slowing down dementia?—a systematic review and a meta-analysis[J]. Nutrients, 2023, 15(2): 386.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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