Welcome Bulk Glutathione powder wholesale price
+86-755-23577295
Recently, a research team from North Sichuan Medical College used proteomics technology to deeply explore the protective effect and molecular mechanism of reduced glutathione (GSH) on acetaminophen (APAP)-induced acute liver injury in mice. This study not only provides a new theoretical basis for clinical treatment, but also lays the foundation for the development of safer and more effective treatments for drug-induced liver injury.
Acetaminophen (APAP) is a widely used antipyretic and analgesic, but due to the toxicity of its metabolite N-acetyl-p-benzoquinone imine, excessive use or combined with other risk factors (such as liver disease, malnutrition, drinking) may cause severe liver damage.
GSH is one of the commonly used drugs for the clinical treatment of liver injury and is widely used to treat heavy metal and organic compound poisoning, hepatitis, etc. GSH in the body is mainly synthesized and consumed in the liver. When liver cells are damaged, GSH synthesis decreases, consumption increases, and the defense ability against oxygen free radicals decreases. Oxygen free radicals cause liver cell membrane damage through lipid peroxidation, intracellular calcium ion loss, and mitochondrial dysfunction, thereby inducing liver cell degeneration and necrosis. Exogenous supplementation of GSH can restore GSH oxidase activity, remove oxygen free radicals, block their damage to liver cells, and thus alleviate liver damage.
The research team of North Sichuan Medical College adopted an innovative research method. They randomly divided 120 mice into three groups and gave them different treatments: blank control group, APAP model group and GSH treatment group. Using SWATH combined with liquid chromatography-tandem mass spectrometry technology, the researchers analyzed the protein expression profile of mouse liver tissue and screened out differential proteins related to liver damage. The results showed that there were 310 differential proteins between the APAP group and the control group, and 172 differential proteins between the GSH treatment group and the APAP group. These differential proteins are mainly concentrated in key metabolic pathways such as nitrogen metabolism, fatty acid metabolism and organic acid metabolism.
More excitingly, the researchers found that GSH may exert its protective effect by inhibiting apoptosis. In APAP-induced liver injury, apoptosis is a key pathological process. The research team verified several key proteins related to apoptosis by immunohistochemistry, and the results showed that GSH may inhibit apoptosis by regulating the expression of these proteins, thereby alleviating liver damage.
The study of North Sichuan Medical College not only revealed the protective mechanism of GSH against APAP-induced liver injury, but also provided new targets for future drug development. The discovery of proteins such as Anxa5, Rgn, Tagln, Vim and Usp5 provides a potential direction for the development of new therapeutic drugs for drug-induced liver injury. In addition, this study also highlights the potential of GSH as a safe and effective therapeutic drug, and its clinical application prospects are worth looking forward to.
With the deepening of this study, we have reason to believe that reduced glutathione will play an important role in the treatment of drug-induced liver injury. Future studies will further explore the mechanism of action of GSH and evaluate its efficacy and safety in human patients. This discovery not only brings new breakthroughs in medical research, but also brings new hope to patients.
[1] Chen Li, Wu Silin, Zhang Chengda, et al. Study on the mechanism of protective effect of reduced glutathione on acute liver injury caused by acetaminophen[J]. Journal of North Sichuan Medical College, 2025, 40(01):13-20.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
GSHWORLD is China Biological API Manufacturer. China Glutathione Supplements powder suppliers & best Glutathione benefits raw material Factory.
