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Nicotinamide ribose chloride is a salt form of nicotinamide ribose (NR). NR is one of the precursors of NAD+. NAD+ is a vital coenzyme in cells. It plays a role in fuel oxidation, ATP production, and gluconeogenesis. It plays a central role in many metabolic processes. As we age, NAD+ levels decrease, which is closely related to metabolic stress and aging. NR, as a supplement, may help maintain NAD+ levels, thereby supporting health and slowing aging.
Increase NAD+ levels: NR can significantly increase whole blood NAD+ levels in a dose-dependent manner, which may improve cellular metabolism and energy production.
Protects the nervous system: In animal models, NR prevented noise-induced hearing loss, heart failure, and central brain damage.
Improves Metabolic Health: NR helps prevent weight gain, fatty liver disease and diabetic peripheral neuropathy caused by a high-fat diet.
Enhanced cell repair: NR improved the survival rate of mice after radiation and the regenerative capacity of hematopoietic stem cells.
In an 8-week randomized, double-blind, placebo-controlled clinical trial, healthy overweight adults took 100, 300, and 1000 mg of NR daily and found that NR was well tolerated.
A European Commission expert panel concluded that nicotinamide riboside chloride is safe for healthy adults at doses up to 300 mg per day.
NR, as a potential vitamin B3, has particularly strong potential to support human health during metabolic stress and aging. It may be ideal for those seeking to improve metabolic health, enhance cellular repair, and combat aging-related diseases.
Although NR shows great potential, its use as a supplement requires more research to determine its long-term effects and optimal dosage. Before starting any supplements, it is recommended to consult a medical professional.
[1] Conze, D., Brenner, C. & Kruger, C.L. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep. 9, 9772 (2019).
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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