What is adenosylmethionine used for?

 

S-Adenosyl-L-methionine (SAMe) is a compound that occurs naturally in the human body and is produced primarily by the liver. It can also be synthesized as a supplement. It plays an important role in several biochemical processes, including methylation, synthesis of neurotransmitters, and more.

1. Health products containing SAMe on the market are considered to be beneficial for the following purposes:

Depression: Multiple studies have proven that SAMe can increase serotonin levels in the brain and is effective in treating depression with relatively few side effects.

Liver disease: SAMe, as a liver nutrient, can alleviate liver damage caused by alcohol and drugs and prevent chronic hepatitis.

Arthritis: SAMe has anti-inflammatory and analgesic effects, and can promote cartilage tissue formation and injury healing.

2.SAMe’s potential health benefits:

Fibromyalgia syndrome: At least four clinical studies have shown that SAMe may be effective in patients with fibromyalgia, significantly reducing the number of pain points and painful areas and improving mood.

Methylation reaction: SAMe, as the main methyl donor in the methylation reaction, is crucial for the synthesis of body components, especially brain chemicals and detoxification reactions.

Synthesis of sulfur-containing compounds: SAMe plays a role in the synthesis of all sulfur-containing compounds in the human body, including glutathione and various sulfur-containing cartilage tissues.

SAMe has appeared on the European pharmaceutical market in the 1970s and is used to treat arthritis. In the U.S. market, SAMe is sold as a nutritional supplement that has the effects of improving mood, protecting the liver and comforting joints. As a new type of drug and food nutritional supplement, SAMe has a variety of biochemical functions. Currently, SAMe is in high demand in the international market, and research on related uses continues to increase. We look forward to SAMe bringing more surprises in the future.

References:

[1] Lee Y H, Ren D, Jeon B, et al. S-Adenosylmethionine: more than just a methyl donor[J]. Natural product reports, 2023, 40(9): 1521-1549.

[2] Peng T R, Cheng H Y, Wu T W. S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis[J]. General Hospital Psychiatry, 2024.

[3] Pascale R M, Simile M M, Calvisi D F, et al. S-adenosylmethionine: From the discovery of its inhibition of tumorigenesis to its use as a therapeutic agent[J]. Cells, 2022, 11(3): 409.

[4] Cuomo A, Beccarini Crescenzi B, Bolognesi S, et al. S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review[J]. Annals of general psychiatry, 2020, 19: 1 -7.

[5] Badaeva A, Danilov A, Kosareva A, et al. Neuronutritional Approach to Fibromyalgia Management: A Narrative Review[J]. Pain and Therapy, 2024: 1-15.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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