What is adenosylmethionine disulfate tosylate?

 

S-Adenosyl-L-Methionine Disulfate Tosylate is the disulfate salt of the stable S-adenosyl-L-methionine (SAM-e) p-tosylate complex with chemopreventive activity.

It is hydrolyzed in cells and converted into the active compound SAM-e.

In recent years, SAM-e has received increasing attention as a supplement, particularly for improving cognitive function and depressive symptoms.

1. Highlights of the study

According to new research, SAM-e has shown the potential to improve cognitive function in animal experiments. Especially for young animals and animals that received long-term SAM-e supplementation, their spatial learning and memory abilities were significantly improved.

In the treatment of depression, SAM-e acts as a natural methyl donor through multiple biochemical pathways, including neurotransmitter synthesis and metabolism and potential epigenetic pathways. The effects of SAM-e are impressive Attention. Combined with probiotic supplementation, this synergistic effect may enhance its effects by improving gut health, as gut dysbiosis has been linked to depression. This provides new options for patients with depression, especially those who do not respond well to traditional treatments.

2. Safety and bioavailability

In terms of safety, SAM-e shows a good record. Oral formulations are the main dosage form of SAM-e, which can be efficiently absorbed by the body and show good tolerance even at high doses.

As a naturally occurring molecule, SAM-e has exciting potential for improving cognitive function and fighting depression. The results of animal studies are encouraging, but more research is needed to verify the effectiveness of SAM-e.

References:

[1] Cameron BR, Ferreira L, MacDonald ID. Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product. BMC Pharmacol Toxicol. 2020 Dec 14;21(1):88. doi: 10.1186/s40360-020-00466-7. PMID: 33317621; PMCID: PMC7734772.

[2] Ullah H, Khan A, Rengasamy KRR, Di Minno A, Sacchi R, Daglia M. The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach. Nutrients. 2022 Jul 1;14(13): 2751. doi: 10.3390/nu14132751. PMID: 35807931; PMCID: PMC9268496.

[3] Zhao Y, Zhang Y, Meng S, Chen B, Dong X, Guo X, Guo F, Zhang R, Cui H, Li S. Effects of S-Adenosylmethionine on Cognition in Animals and Humans: A Systematic Review and Meta -Analysis of Randomized Controlled Trials. J Alzheimers Dis. 2023;94(s1):S267-S287. doi: 10.3233/JAD-221076. PMID: 36970898; PMCID: PMC10473070.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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