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S-adenosylmethionine (SAM-e) is a molecule that plays various biological functions in the human body. It is an important methyl donor that participates in more than 100 different biochemical reactions in the human body and is essential for life-sustaining activities. As a multifunctional bioactive molecule, it plays an indispensable role in human health. Its applications range from liver protection to neuroprotection.
In a 12-month study of patients with non-alcoholic fatty liver disease (NAFLD), the most common liver disease, combined supplementation with SAM and S-adenosyl-L-methionine (SAMe) significantly improved overall health outcomes. Cholesterol, insulin levels and insulin resistance index (HOMA-IR), while reducing serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels.
In addition to its application in the treatment of liver diseases, SAM also shows great potential in neuroprotection. SAM-e has an auxiliary therapeutic effect on neuropsychiatric diseases such as depression, Alzheimer's disease (AD), and Parkinson's disease (PD). It protects nerve cells by promoting the synthesis of neurotransmitters, improving cell signaling, and enhancing the antioxidant defense system.
In vitro and animal studies of the dietary supplement S-adenosylmethionine have shown that SAMe can stimulate cartilage production, which is critical for reversing the disease process of osteoarthritis. Researchers studied a number of potential mechanisms of action, including: reducing inflammatory mediators; increasing glutathione levels; direct or indirect signaling for cartilage synthesis or survival; and maintaining DNA methylation, which may help reduce pain and stiffness in patients. feel.
With further research on its biological function, pharmacological activity, stability and tolerance, SAM-e is expected to play a greater role in the future medical and health field. With the continuous advancement of science and technology, we have reason to believe that SAM-e will bring more benefits to human health.
[1] Lee Y H, Ren D, Jeon B, et al. S-Adenosylmethionine: more than just a methyl donor[J]. Natural product reports, 2023, 40(9): 1521-1549.
[2] Peng T R, Cheng H Y, Wu T W. S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis[J]. General Hospital Psychiatry, 2024.
[3] Zhang Y, Ma R, Deng Q, et al. S-adenosylmethionine improves cognitive impairment in D-galactose-induced brain aging by inhibiting oxidative stress and neuroinflammation[J]. Journal of Chemical Neuroanatomy, 2023, 128: 102232.
[4] Giangrandi, Ilaria & Dinu, Monica & Pagliai, Giuditta & Sofi, Francesco & Casini, Alessandro. (2016). Efficacy of Oral Supplementation with Silymarin and S-Adenosyl-L-Methionine in Patients with Non Alcoholic Fatty Liver Disease – A Pilot Study. Alternative & Integrative Medicine. 05. 10.4172/2327-5162.1000224.
[5] de Carvalho J F, Churilov L P, Lerner A, et al. S-adenosylmethionine therapy in rheumatic and related autoimmune diseases[J]. 2023.
[6] Hosea Blewett H J. Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis[J]. Critical reviews in food science and nutrition, 2008, 48(5): 458-463.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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