What does NAD+ do in the body? How do I get NAD+?

 

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that plays a key role in cellular energy metabolism and signal transduction. With the deepening of scientific research, the importance of NAD+ in maintaining cell homeostasis, aging, longevity, immune system and DNA repair has gradually been revealed.

1. What is the role of NAD+?

NAD+ plays multiple roles in cells. First, it is an indispensable part of cellular energy metabolism and participates in key metabolic processes such as glycolysis, oxidative phosphorylation, fatty acid oxidation and tricarboxylic acid cycle. In addition, NAD+ also serves as a substrate for a variety of signaling enzymes, including deacetylases (such as sirtuins), ADP ribose polymerases (PARPs) and cADPRSs, and participates in non-redox reactions such as DNA damage repair, cell signal transduction, inflammatory response, cell aging and apoptosis.

2. How should NAD+ be obtained?

The main way to obtain NAD+ is to supplement it by consuming NAD+ precursors. These precursors include NMN and NR, which can be found in a variety of daily foods, such as milk, fruits, vegetables and meat. NMN and NR are converted into NAD+ in cells through specific metabolic pathways, thereby supporting the physiological functions of cells.

3. NAD+ Precursors: NMN and NR

NMN and NR are direct precursors of NAD+, which are converted into NAD+ in cells through specific enzymes. NMN is an important intermediate in the NAD+ synthesis pathway and can directly generate NAD+ through enzymatic reactions in cells. NR, on the other hand, participates in the synthesis of NAD+ by converting into NMN. Studies have shown that the supplementation of NMN and NR can effectively increase the level of NAD+ in cells, and has a potential positive effect on improving aging-related symptoms and metabolic diseases.

4. The role of NAD+ in human aging

With age, the level of NAD+ in the body gradually decreases, which is associated with the development of a variety of aging-related diseases, including neurodegenerative diseases, metabolic diseases, and decreased immune function. Supplementing NAD+ or its precursors may help slow the aging process and improve aging-related health conditions.

NAD+ is a key molecule for maintaining cell function and promoting healthy aging. A proper diet and supplementation with NAD+ precursors, such as NMN and NR, can help maintain NAD+ levels in the body and fight aging and various chronic diseases.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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