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Pyrroloquinoline Quinone disodium salt (PQQ) is a compound with multiple biological activities. As an emerging dietary supplement, it has shown its potential health benefits in multiple fields.
Research shows that PQQ has a positive impact on cognitive function in adults of all ages. In adults between the ages of 20 and 65, participants who supplemented with 20 mg of PQQ daily for 12 weeks experienced significant improvements in compound memory and verbal memory abilities. Particularly in young adults (20 to 40 years old), PQQ improved cognitive flexibility, processing speed, and execution speed. Additionally, the combination of PQQ and CoQ10 further enhances these effects.
PQQ has powerful antioxidant capabilities and can protect brain cells from oxidative stress and free radical damage. By modulating NMDA receptors and activating the Akt/GSK3β signaling pathway, PQQ helps slow the progression of neurodegenerative diseases. In addition, PQQ also has anti-inflammatory effects and can reduce inflammation in the brain, thereby protecting cognitive function.
Not only are PQQ supplements good for the brain, they also have positive effects on muscle strength and physical performance. In a randomized, double-blind, placebo-controlled study, healthy volunteers supplemented with 21.5 mg of PQQ disodium salt daily for 12 weeks showed significant improvements in lower limb extensor muscle strength and grip strength. In addition, the physical function results of the 10-meter turn-back walk test, 6-minute walk test, and 10-meter walk test were significantly improved.
In addition to the above benefits, PQQ supplementation may also be beneficial in reducing stress, improving sleep quality, improving skin's moisture retention capacity, and supporting muscle and metabolic health during exercise training.
As a functional food, PQQ's high-purity production ensures safety and effectiveness. As research on PQQ continues, we expect this supplement to further confirm its potential in clinical trials in the future to promote body homeostasis, improve fat metabolism, and combat age-related diseases.
[1] Baltic S, Nedeljkovic D, Todorovic N, et al. The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial[J] . The Journal of nutrition, health and aging, 2024, 28(8): 100287.
[2] Ikemoto K, Ishak N S M, Akagawa M. The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes[J]. The Journal of Medical Investigation, 2024, 71(1.2): 23-28.
[3] Tamakoshi M, Suzuki T, Nishihara E, et al. Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults[J]. Food & Function, 2023, 14(5): 2496-2501.
[4] Shiojima Y, Takahashi M, Takahashi R, et al. Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study[J] . Journal of Functional Foods, 2024, 113: 106012.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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