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Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine, and is widely present in human cells. It is one of the most important antioxidants in the human body. Glutathione plays a key role in maintaining cellular homeostasis, detoxification, and regulating protein function. In recent years, glutathione supplements, as a type of dietary supplement, have attracted widespread attention, and their potential health benefits have also been the subject of numerous studies.
Glutathione is one of the most important antioxidants within cells, capable of neutralizing free radicals and reducing the damage caused by oxidative stress to cells. Oxidative stress is closely related to the occurrence and development of many chronic diseases, such as cardiovascular diseases, cancer, and neurodegenerative diseases. In theory, supplementing with glutathione can enhance the body's antioxidant capacity, thereby potentially preventing and aiding in the treatment of these diseases. For example, some studies have shown that glutathione supplements can significantly reduce the serum alanine aminotransferase (ALT) levels in patients with non-alcoholic fatty liver disease (NAFLD), indicating that it may be beneficial to liver health.
Glutathione also shows certain potential in skin health. Some research has found that glutathione supplements can reduce the melanin index in the skin and decrease wrinkles, thereby exerting whitening and anti-aging effects. The mechanism may be related to the antioxidant properties of glutathione. By reducing the damage caused by free radicals to skin cells and promoting the synthesis of collagen, it can improve the overall condition of the skin.
Glutathione also plays an important role in the nervous system. It can protect nerve cells from oxidative stress damage and may have potential value in the treatment of neurodegenerative diseases such as Parkinson's disease. However, most of the current research is still in the preliminary stage, and more clinical trials are needed to verify its actual effects in neuroprotection.
In addition, studies have found that the effects of glutathione supplements may vary depending on the dosage and duration of supplementation. Lower doses may not significantly increase glutathione levels, while higher doses may be more effective in some populations. The length of supplementation also affects glutathione levels.
As a dietary supplement, glutathione supplements have a variety of potential health benefits, especially in terms of antioxidant, skin whitening and anti-aging, and neuroprotective effects.
Mangkalopakorn P, Segsarnviriya C, Keeratipranon M, et al. Glutathione Levels after Glutathione Supplementation: A Systematic Review and Meta-analysis[J]. Journal of Current Science and Technology, 2025, 15(1): 90-90.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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