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PQQ is a compound that occurs naturally in certain foods and is also available as a dietary supplement in the form of its disodium salt crystals. It has been widely studied for its antioxidant and anti-inflammatory properties. What's more, PQQ has significant effects on the function of mitochondria, the organelles within cells responsible for energy production, whose dysfunction has been linked to health problems such as obesity.
According to the latest research, PQQ reduces fat accumulation through multiple mechanisms. First, it inhibits lipogenesis, the process by which the body synthesizes new fat molecules from non-fat sources. Secondly, PQQ increases mitochondrial number and function, thereby improving lipid metabolism. In addition, PQQ can also reduce the risk of obesity by improving the composition of intestinal flora, which has been confirmed in high-fat diet animal models.
Obesity is associated with a chronic low-grade inflammatory state that exacerbates mitochondrial dysfunction, creating a vicious cycle. PQQ's anti-inflammatory properties help break this cycle. Studies have shown that PQQ can reduce the production of inflammatory factors, such as tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), etc., thereby reducing the damage of inflammation to mitochondrial function.
In addition to reducing fat accumulation, PQQ has shown potential benefits in obesity-related metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and chronic kidney disease. These diseases are all associated with mitochondrial dysfunction and inflammation, and PQQ helps mitigate the progression of these diseases by improving mitochondrial function and reducing inflammation.
The safety of PQQ as a food ingredient has been recognized by the European Food Safety Authority. Although there is currently a relative lack of human research on PQQ, existing studies have shown that PQQ has many positive effects on human health. In the future, more research will focus on the pharmacokinetics of PQQ, optimal dosage and timing of intake, and potential synergistic effects with other lifestyle interventions such as diet and exercise.
In summary, PQQ, as an emerging dietary supplement, provides us with a new strategy to combat obesity and related diseases.
[1] Charrier D, Cerullo G, Carpenito R, et al. Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives[J]. Antioxidants, 2024, 13(9) ): 1027.
[2] Mohamad Ishak N S, Ikemoto K. Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression[J]. Frontiers in Molecular Biosciences, 2023, 10: 1200025.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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