Cosmetic raw materials are properly formulated and processed to adjust the texture, color, fragrance, moisturizing, antioxidant, anti-inflammatory, whitening, sun protection, exfoliation and other functions of cosmetics. In recent years, with the continuous expansion of the global cosmetics market and consumers' increasing demand for product efficacy, safety and environmental protection, new, efficient and safe raw materials have gradually taken over. The selection, formula and dosage of cosmetic raw materials have an important impact on the quality of cosmetics. Safety, efficacy and potency have a direct impact.
As a NAD+ precursor, NMN has multiple functions by increasing NAD+ levels, activating sirtuins proteins, promoting NADPH synthesis, and assisting DNA repair. It can prevent damage to keratinocytes caused by ultraviolet radiation and help prevent and treat skin photoaging. NMN can be used as a skin protectant and moisturizer in various skin cosmetics, except for products that may be inhaled, such as sprays and powders.
PQQ has strong antioxidant ability, can scavenge free radicals, protect cells from oxidative damage, and can also stimulate the activity of collagenase. It can be added as a skin protectant to various cosmetics except spray products. Its antioxidant, The ability to promote collagen synthesis helps enhance skin repair, reduce inflammation and blemishes, help improve skin texture, and delay skin aging.
Experimental studies have shown that adenosine has anti-inflammatory effects, can effectively regulate capillary blood circulation, and reduce skin swelling in a timely manner. Adenosine also has the ability to stimulate the synthesis of new collagen, improve skin elasticity and hydration, and reduce wrinkles and skin irritation. Signs of aging and can be used in cosmetics as a skin conditioner.
Studies have shown that glutathione derivatives can whiten skin and enhance skin permeability and transdermal absorption, thereby improving skin color and condition. At the same time, it accelerates the exfoliation of the cuticle to avoid pigmentation.
Glutathione can also be used in combination with vitamin C, lipoic acid, and grape seed extract to help enhance the antioxidant effect of the skin.
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[1] Zhou X, Du HH, Long 2021 Oct 7;14:5165-5182. doi: 10.2147/JIR.S327329. PMID: 34675595; PMCID: PMC8504657.
[2] Marucci G, Buccioni M, Varlaro V, Volpini R, Amenta F. The possible role of the nucleoside adenosine in countering skin aging: A review. Biofactors. 2022 Sep;48(5):1027-1035. doi: 10.1002 /biof.1881. Epub 2022 Aug 18. PMID: 35979986; PMCID: PMC9804842.
[3] Wahab S, Anwar AI, Zainuddin AN, Hutabarat EN, Anwar AA, Kurniadi I. Combination of topical and oral glutathione as a skin-whitening agent: a double-blind randomized controlled clinical trial. Int J Dermatol. 2021 Aug; 60(8):1013-1018. doi: 10.1111/ijd.15573. Epub 2021 Apr 19. PMID: 33871071.
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