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In modern life, as people become more health conscious, more and more people are paying attention to how to maintain good health through diet and supplements.
Coenzyme Q10 is a vitamin-like molecule that exists in oxidized (ubiquinone) and reduced (ubiquinol) forms in cell membranes and mitochondria. This molecule is particularly abundant in tissues with high energy demands, such as the heart, skeletal muscle, and neurons. The antioxidant activity of Coenzyme Q10 helps to mitigate oxidative damage and regenerate other antioxidants, such as vitamins C and E. Fish, chicken, and herring are the main sources of Coenzyme Q10 in the daily diet.
Creatine phosphate plays a key role in systems with high energy demands, such as the central nervous system and muscle system. It releases energy by degradation, helping cells maintain ATP supply when they are deprived of oxygen or when mitochondrial function is impaired. Creatine phosphate supplements are widely used to improve athletic performance and improve sarcopenia in the elderly.
PQQ is a known energy-related metabolic and neuroprotective agent. It works through cell signaling and enhanced mitophagy and mitochondrial function. PQQ is abundant in a variety of foods such as fermented soybeans, tea, and green peppers, and plays an important role in maintaining NAD+ levels, optimizing mitochondrial function, and inhibiting oxidative stress.
Lipoic acid is an important component of mitochondrial structure. It acts as a cofactor in enzymatic reactions in aerobic pathways and coordinates energy metabolism. Although the human body can synthesize lipoic acid on its own, it usually needs to be supplemented through diet, especially red meat, liver, and certain vegetables. Lipoic acid supplements have strong antioxidant capacity and can regenerate other antioxidants.
NAD metabolism is a complex and dynamic process that plays a vital role in the health of organisms. NAD+ levels also decline in premature aging and lead to metabolic dysfunction and overall health decline observed during aging. Both NR and NMN can be used to make NAD+ in the salvage pathway.
Through proper diet and supplementation, we can effectively support mitochondrial health, thereby improving quality of life and preventing disease. When choosing a supplement, it is recommended to consult a medical professional to ensure safety and effectiveness.
[1] Golubnitschaja O, Kapinova A, Sargheini N, Bojkova B, Kapalla M, Heinrich L, Gkika E, Kubatka P. Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation. EPMA J. 2024 Apr 18;15(2):163-205. doi: 10.1 007/s13167-024-00358-4. PMID: 38841620; PMCID: PMC11148002.
[2] Chini CCS, Cordeiro HS, Tran NLK, Chini EN. NAD metabolism: Role in senescence regulation and aging. Aging Cell. 2024 Jan;23(1):e13920. doi: 10.1111/acel.13920. Epub 2023 Jul 9. PMID: 37424179; PMCID: PMC10776128.
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