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Nicotinamide Riboside Chloride (NRCl) is a novel vitamin B3 derivative that has attracted much attention in recent years for its potential benefits in anti-aging, metabolic health, and neuroprotection.
NRCl is the chloride salt form of Nicotinamide Riboside (NR), which itself is a precursor of Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme that plays a key role in cellular energy metabolism, DNA repair, and cell signaling.
NRCl has good stability and usually exists in a crystalline form, which has advantages in manufacturing and quality control. Crystalline NRCl is relatively stable under dry and light-proof conditions, but may degrade under high humidity or long-term light exposure.
The potential health benefits of NRCl mainly come from its enhancement of NAD+ levels. NAD+ plays a key role in cellular energy metabolism, and as we age, NAD+ levels in the human body gradually decline, which is considered an important sign of aging. Studies have shown that NRCl supplementation may slow the aging process, improve mitochondrial function, and enhance cellular metabolism by increasing NAD+ levels.
In terms of metabolic health, NRCl is believed to improve insulin sensitivity, regulate lipid metabolism, and have a positive impact on metabolic diseases such as obesity and diabetes. In addition, NRCl has shown neuroprotective effects and may help prevent neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In terms of cardiovascular health, NRCl may work by improving vascular function, reducing inflammation, and lowering blood pressure.
NRCl has a higher bioavailability than other vitamin B3 derivatives such as niacinamide and niacin. This makes NRCl more effective in supplementing NAD+. NRCl is also more bioavailable than other natural compounds such as resveratrol and quercetin, which means that it can exert significant physiological effects at lower doses.
As a novel NAD+ precursor supplement, NRCl has attracted widespread attention due to its potential benefits in anti-aging, metabolic health, and neuroprotection. Its good bioavailability and stability make it a promising dietary supplement. However, despite the promising research prospects of NRCl, more clinical trials are needed to further verify its long-term safety and optimal dosage.
Jain R, Tiwari A. Nicotinamide Riboside: An Update[J]. Matrix Science Pharma, 2024, 8(3): 62-64.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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