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NMN is used in the production of NAD+, which provides the energy our cells need to function. Several factors are thought to underlie the aging process, a lack of cellular energy being one of them. Genetic instability due to DNA damage is also one of these factors. NAD+ plays a key role in activating enzymes that maintain DNA integrity, thereby promoting genetic stability. Given its central role in these cellular processes, the potential benefits of using NMN to boost NAD+ extend to virtually all body systems.
Obesity is associated with a range of metabolic defects, including insulin resistance -- when cells are unable to use glucose due to impaired insulin signaling -- which leads to diabetes. Mitochondria are the final cellular destination for the conversion of the food we eat into energy, making them vital in metabolism and related diseases. NMN has been shown to double the number of mitochondria in the liver of obese mice, which protects against obesity. Stimulating lipolysis with NMN can also help obese people lose fat. In addition, NMN improved the metabolism and health of mice born to obese mothers.
Eating too much and becoming obese can wreak havoc on our metabolism and can lead to diabetes. Aging makes both of these conditions worse. In mice, NMN has been shown to reverse diet- and age-induced diabetes and prevent diabetes-related kidney disease and neuronal degeneration, suggesting that NMN protects against these metabolic disorders. In support of this, NMN has been shown to improve muscle insulin sensitivity in older women. Therefore, while lifestyle adjustments such as consistent exercise and a healthy diet are crucial, NMN can protect against obesity and diabetes.
Macular degeneration is an age-related disease that involves the degeneration of the area of the retina that allows us to see clearly. Therefore, more severe forms of macular degeneration can lead to blindness. NMN has been shown to repair mitochondrial dysfunction associated with macular degeneration in mice.
As we age, our eyes can become dry and inflamed. NMN has been shown to reduce inflammation and increase oil production to treat dry eye in mice. NMN has also been shown to reduce cell death and wound size following eye injury.
In addition to slowing aging in the brain, vasculature, muscles, heart, metabolism and eyes, NMN has been shown to rejuvenate skeletal stem cells and promote bone formation in rodents. It also reversed intestinal aging, prevented age-related kidney degeneration, and inhibited the development of liver fibrosis in rodents. Therefore, NMN can also slow down the aging of bones, intestines, kidneys and liver.
The core of NMN anti-aging lies in the transformation and improvement of NAD+. Its effects on improving the aging condition of the human body and delaying aging are all realized by converting into NAD+, which is the direct precursor of NAD+. After oral administration of NMN, this substance can enter the blood within 2-3 minutes, and be absorbed by body organs within 30 minutes, transform into NAD+, increase its content, and then use the influence of NAD+ on the body to exert its effect on the human body.
Our DNA codes make up the building blocks of our cells, but accumulate damage as we age. Repairing DNA damage can prevent age-related diseases. NAD+ fuels enzymes called sirtuins—sometimes considered the guardians of our healthy lifespan. Sirtuins play a key role in repairing DNA.
Additionally, each time our cells divide, the DNA at the end of our chromosomes (telomeres) gets shorter. At some point, this telomere shortening starts to damage our genes and cells. Sirtuins slow down this process by stabilizing telomere length.
Since sirtuins depend on NAD+ to function, efforts have been made to enhance sirtuin activity through NAD+ enhancing methods. Along these lines, studies have shown that feeding mice NMN activates sirtuins. NMN can also repair DNA damage caused by radiation and aging in mice. Furthermore, NMN increases telomere length in both mice and humans.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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