Questions and answers about Pyrroloquinoline Quinone (PQQ) Supplements

 

Pyrroloquinoline Quinone (PQQ) is a vitamin-like compound with multiple biological functions and health benefits. According to the literature, PQQ supplements can improve brain cognitive function, enhance exercise recovery, repair liver damage, improve osteoporosis, etc. It promotes mitochondrial growth and development by affecting mitochondrial biogenesis and energy metabolism, exhibits antioxidant properties, effectively removes free radicals, and reduces cell damage. In addition, PQQ also shows neuroprotective effects and has potential protective effects in models of various neurodegenerative diseases.

1. Where does PQQ exist naturally and what foods are rich in PQQ?

PQQ is widely present in various biological tissues, including human breast milk, plant and animal foods. According to the literature, foods rich in PQQ include tea, fermented soybeans (such as natto), kiwi, peppers, parsley, etc. PQQ can be ingested through daily diet, but its specific content may vary depending on the type of food and processing method.

2. Safety of taking PQQ every day:

Many studies have shown that PQQ supplements are safe at reasonable doses. In animal experiments and clinical studies, PQQ showed low toxicity, and no obvious toxic reactions were observed in subchronic toxicity tests. The US FDA has listed PQQ as a GRAS (generally recognized as safe) substance, and there are studies that support that PQQ is safe for humans within the prescribed dosage range.

3. Anti-aging effects of PQQ:

PQQ shows potential anti-aging effects by promoting mitochondrial function and improving the antioxidant capacity of cells. In animal models, PQQ can prolong life and improve cognitive function decline associated with aging. The specific effects and mechanisms of PQQ as an anti-aging supplement are still under further study.

4. Benefits of PQQ to the liver:

PQQ is beneficial to the liver and can reduce liver damage through antioxidant and anti-inflammatory effects. In animal models, PQQ can improve non-alcoholic fatty liver disease caused by a high-fat diet, reduce serum liver enzyme levels, and improve liver antioxidant capacity.

5. Anti-inflammatory effects of PQQ:

PQQ has anti-inflammatory effects and can reduce the production of inflammatory factors by regulating inflammation-related signaling pathways. In animal models, PQQ was able to reduce exercise-induced muscle damage and inflammation, as well as reduce neuroinflammation in neurodegenerative disease models.

6. PQQ helps with weight loss:

Although PQQ's primary effect is not direct weight loss, it may have a positive effect on weight management by improving metabolism and energy balance. PQQ can improve mitochondrial function and energy metabolism, which may help improve the body's efficiency in using energy, thereby indirectly affecting weight loss. Of course, research in this area is not sufficient and more clinical studies are needed to verify it.

References:

[1] Jonscher K R, ChowaNADisai W, Rucker R B. Pyrroloquinoline-quinone is more than an antioxidant: a vitamin-like accessory factor important in health and disease prevention[J]. Biomolecules, 2021, 11(10): 1441.

[2] Shiojima Y, Takahashi M, Takahashi R, et al. Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers: A randomized, double-blind, placebo-controlled study[J]. Journal of Functional Foods, 2024, 113: 106012.

[3] Canovai A, Williams P A. Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism[J]. Neural Regeneration Research, 2025, 20(1): 41-53.

[4] Li Zhongzhu, Yang Yang. Research progress on functional properties of pyrroloquinoline quinone and its products[J]. Journal of Food Safety and Quality, 2023, 14(22): 252-258. DOI: 10.19812/j.cnki.jfsq11-5956/ts.2023.22.015.

[5] Che Lu. Research on the development of new vitamin compound PQQ in the food field from the perspective of patents[J]. China Food, 2022, (22): 106-108.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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