PQQ’s new potential?

 

PQQ is a quinone cofactor, considered a "new vitamin" and plays an important role in the growth, reproduction and development of mammals. It acts as an enzyme cofactor that increases oxidative phosphorylation and ATP production. PQQ is found in many foods, such as parsley, green peppers, spinach, kiwi fruit and soybeans.

Recently, researchers have studied the neuroprotective effect of PQQ on retinal ganglion cells, and the results indicate that PQQ, as a neuroprotective agent, may have the right to resist the death of retinal ganglion cells (RGC).

1.PQQ has neuroprotective effects

Studies have found that PQQ has neuroprotective effects in different RGC-related injury models, and PQQ can effectively prevent RGC and retinal cell loss.

2.PQQ can increase ATP content

In order to study the effect of PQQ on neuronal ATP, the researchers measured the ATP content levels in cortical cells incubated with different doses of PQQ (0.1, 0.5, 1, 5, 10, 50 μM) for 2 hours. Starting from a concentration of 0.5 μM, the levels of ATP in cortical cells The ATP content increased significantly.

▲The effect of PQQ administration on ATP in vitro

In addition, when researchers treated adult mice with PQQ, they also observed significant increases in ATP levels in the retina, optic nerve, and superior colliculus.

▲The effect of PQQ administration on ATP levels in visual system tissues in vivo.

Studies have found that PQQ has a slight effect on mitochondrial content. Metabolic changes and mitochondrial dysfunction occur early in many retinal diseases. Improving metabolism and mitochondrial function and increasing ATP content can effectively combat RGC damage. In the study, PQQ can quickly increase ATP concentration, which shows that PQQ Has potential as an auxiliary supplement for retinal diseases.

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Literature source:

[1] Canovai A, Tribble JR, Jöe M, Westerlund DY, Amato R, Trounce IA, Dal Monte M, Williams PA. Pyrroloquinoline Quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection. Acta Neuropathol Commun. 2023 Sep 8;11(1):146. doi: 10.1186/s40478-023-01642-6. PMID: 37684640; PMCID: PMC10486004.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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