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The preventive effect of NMN on cancer is mainly reflected in reducing the risk of cancer and enhancing the curative effect of cancer:
Maintain the stability of mitochondria, prevent and delay the occurrence of tumors and neurodegenerative diseases
A review published in Curr Med Chem in 2021, summarizing many studies related to NMN and mitochondria, found that maintaining the concentration of NAD+ and maintaining a better concentration ratio of NAD+/NADH is beneficial to maintaining the normal function of mitochondria and helping to maintain Catalytic activity of various NAD+ consuming enzymes related to senescence regulation, such as Sirtuins, poly ADP-ribose polymerase and CD38/157 enzymes.
Thus, NAD+ supplementation, including NMN, could serve as a potential preventive measure against tumors.
Studies published in Cancer Cell in 2014 and Oncoscience in 2015 showed that during the occurrence of oncogene-induced hepatocellular carcinoma (HCC), NAD+ synthesis was inhibited, resulting in difficulty in repairing DNA damage, which is an important factor in the occurrence of cancer. reason. If NAD+ is supplemented in time after oncogene activation and before HCC occurs, liver health can be maintained to a certain extent and tragedy can be avoided.
A mammalian study published in Free Radic Biol Med in 2021 found that NMN inhibition can effectively prevent the occurrence and development of liver fibrosis, so supplementing NMN is a new strategy to prevent liver cirrhosis and liver cancer caused by liver fibrosis.
The pathogenesis and development mechanism of cancer is very complex and has not yet been fully understood. Then, judging from the existing information, the "beneficiary" therapies for different cancers are different.
In recent years, it has been confirmed that NMN plays an active role in immunotherapy (PD-L1-related), CAR-T therapy and other cancer therapies through mechanisms such as delaying immune cell aging and enhancing immune cell function.
PD-L1 is a protein often expressed on the surface of tumor cells and associated with tumor immune escape. If there is enough PD-L1 on the surface of tumor cells, the effect of immunotherapy on tumor cells will be better, and it will be less likely to damage healthy cells.
In 2020, a study published on Cell Metabolism by Dongfang Hepatobiliary Hospital of Second Military Medical University and Cancer Hospital Affiliated to Fudan University showed that if NAD+ is sufficient, it can trigger the NAMPT-TET1-p-STAT1-IRF1-PD-L1 cellular cascade reaction, Promotes higher levels of PD-L1 protein expression on the surface of cancer cells, thereby enhancing the cancer treatment effect of immunotherapy.
In April 2022, a study to be published by Beijing Shijitan Hospital of Capital Medical University showed that NMN has an adjuvant effect on CAR-T (Chimeric Antigen Receptor Modified T Cell Targeted Therapy, which is used for the treatment of hematological malignancies) .
NMN can enhance the NAD+ level in CAR-T cells, protect the telomere length of CAR-T cells, improve the proliferation ability of CAR-T cells, and reduce apoptosis, thus enhancing the efficacy and lifespan of CAR-T.
Therefore, it can be seen that supplementing NMN can effectively reduce the risk of cancer and enhance the efficacy of cancer treatment.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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