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Recently, the State Food and Drug Administration announced the information on the approval of NMN as a new raw material for "cosmetics".
Previously in 2021, the State Administration for Market Regulation issued the "Letter on Investigating the Illegal Operation of "Elixir", which clearly restricted the food production and operation of NMN within the territory of my country, and conducted a comprehensive investigation of relevant operators. The industry believes that. , this time NMN substances have released a great policy favorable signal through the filing of new raw materials for "cosmetics". Currently the substance can be used in cosmetics, and it is likely to be approved for use in dietary supplements in the future.
The full name of NMN is "β-Nicotinamide Mononucleotide", which is the precursor of NAD+ (coenzyme I), which is closely related to energy metabolism, glycolysis, DNA replication and other activities in the human body.
The Interdisciplinary Research Center of Biology and Chemistry of the Chinese Academy of Sciences pointed out that one of the main reasons for human aging is the decline of NAD+ levels in the body. NMN is the most efficient and direct synthesis pathway of NAD+.
Harvard professor David Sinclair, published in Cell in 2013, showed that supplementation with NMN in 22-month-old mice reversl mitochondrial function in their muscles to 6 months. A large level, which is equivalent to reverting humans from 60-70 years old to 20-30 years old. Therefore, NMN, which can increase the level of NAD+ in the human body, is considered to be a substance with anti-aging function.
In order to study the influence and safety of NMN on human physiology, in recent years, top scientific research institutions such as Harvard Medical School, Washington University School of Medicine, and Keio University School of Medicine in Japan have carried out a number of studies.
In January 2020, Keio University in Japan publicly stated that after 4 years of human clinical trials, NMN has been confirmed to be safe to use.
It is reported that this trial is the result of a collaborative study with the University of Washington, Professor Hiroshi Ito and the University of Washington, confirming that 500 mg of NMN per day is safe. Since 2016, the research team has been conducting a clinical study with a group of healthy men between the ages of 40 and 60. Administer 100 mg, 250 mg, and 500 mg of NMN orally at one time to the same person. At all doses, blood and urine tests after ingestion revealed no changes in blood pressure and pulse, abnormal liver and kidney function, and no effect on eye function or sleep.
In July 21, the results of another human clinical trial of NMN carried out at Guangzhou Sports University were released. This experiment is the first human clinical trial of NMN in China so far.
In February 2022, the domestic human clinical trial targeting NMN/NAD+ transcriptome was approved by the ethics review at Shanghai Changzheng Hospital. This experiment is China's first NMN human clinical trial conducted in a tertiary hospital, marking the beginning of my country's research on nicotinamide mononucleotide (NMN) has entered a serious clinical evidence-based stage. The purpose of this experiment is to study the effect of NMN-NAD+ signaling pathway on the human transcriptome level in healthy people after taking NMN. It is the first time in the world to quantitatively analyze the new quantitative biomarkers characteristic of human aging, which is of great significance.
As the safety of NMN has been continuously confirmed, the regulatory systems of NMN products in various countries are also not adjusted. For example, NMN is a common food in Japan, a dietary supplement in the United States, and a natural health product in Canada.
NMN is currently newly approved as a cosmetic raw material in my country, and it is still in the 3-year safety monitoring period. During the 3-year safety monitoring period, if there is no relevant safety problem, it will be included in the cosmetic raw material catalog according to law. If during the monitoring period, similar raw materials are found to have adverse reactions or group adverse events, the technical review agency will decide whether to cancel the registration or record after evaluating the analysis results.
Under the background that effective skin care has become the main trend and the rise of the ingredient party, the filing of cosmetic raw materials tends to be strictly tightened. On the one hand, the approval of NMN means official recognition of its strong efficacy; on the other hand, the current concept of functional ingredients of downstream brands is similar Qualitative, relevant brands are making arrangements in advance to strive for a first-mover advantage in NMN. It is expected that NMN will usher in a new round of upsurge.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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