How to use S-adenosylmethionine?

 

Adenosylmethionine (SAMe) is an important physiologically active substance in the human body. It has a wide range of applications and affects metal detoxification, gene expression, cell growth, differentiation and apoptosis.

1.Synthesis of adenosylmethionine

Through the action of methionine adenosyltransferase in the body, adenosine triphosphate (ATP) and methionine react to produce adenosylmethionine.

In 1951, Cantoni discovered the enzymatic formation of SAM through nucleophilic transfer of the adenosine moiety of ATP to the sulfur atom of L-methionine, which has since been widely used in the treatment of liver diseases.

2.Application fields of adenosylmethionine

①Clinical application:

SAMe is the main drug for cholestatic liver disease due to its action mechanisms such as transmethylation, transsulfation, and transpropylation. It plays a role in many liver diseases, such as viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, and autoimmune diseases. Many common chronic liver diseases such as chronic hepatitis are accompanied by a considerable proportion of cholestasis. As a methyl donor, SAMe can prevent cholestasis.

In addition, it is also used in the prevention of neurological diseases and is used as an auxiliary treatment for depression, Alzheimer's disease, cognitive impairment, etc.

②Applications in health field:

In 1999, SAMe was used as an over-the-counter drug and dietary supplement in the United States. It was mainly used to improve liver health and relieve osteoarthritis pain and depression symptoms.

There are also studies proving that SAMe as a nutritional supplement is expected to be beneficial to fatty liver and endothelial dysfunction and improve these chronic pathological conditions.

We are a high-tech enterprise with enzyme catalysis technology in the field of synthetic biology as its core. The "enzymatic synthesis coupled with ATP regeneration platform" technology developed and constructed has matured. Using this platform technology, the company has achieved low-carbon production of reduced glutathione, Nicotinamide Mononucleotide, and Citicoline Sodium. It is sold in more than 70 countries and regions around the world and is well received by customers.

references:

[1] Pascale RM, Simile MM, Calvisi DF, Feo CF, Feo F. S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent. Cells. 2022 Jan 25;11(3):409 . doi: 10.3390/cells11030409. PMID: 35159219; PMCID: PMC8834208.

[2] Vergani L, Baldini F, Khalil M, Voci A, Putignano P, Miraglia N. New Perspectives of S-Adenosylmethionine (SAMe) Applications to Attenuate Fatty Acid-Induced Steatosis and Oxidative Stress in Hepatic and Endothelial Cells. Molecules. 2020 Sep 15;25(18):4237. doi: 10.3390/molecules25184237. PMID: 32942773; PMCID: PMC7570632.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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