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S-Adenosyl-L-Methionine (SAM-e) is a sulfur compound present in the human body and is a metabolite of methionine (an essential amino acid). SAM-e plays a variety of biological roles in the body, including serving as a methyl donor for methylation reactions and participating in a variety of biochemical pathways, such as the methylation of DNA, RNA and proteins, and the synthesis of cell membrane phospholipids. These processes are critical to cellular function and metabolism, affecting gene expression, cell signaling, and cell membrane fluidity. SAM-e is also a key substance in the synthesis of neurotransmitters such as dopamine, serotonin (serotonin) and norepinephrine, and is therefore closely related to mood regulation and cognitive function.
The benefits of SAM-e include positive effects on mood and cognitive function, showing significant results in the treatment of depression. Research shows that SAM-e can increase serotonin levels and improve depressive symptoms, and may work faster than traditional antidepressants. In addition, SAM-e also has anti-inflammatory effects, can reduce the production of inflammatory mediators, and is beneficial to chronic inflammatory diseases such as irritable bowel syndrome. SAM-e also shows a protective effect on the liver and can improve liver function indicators and hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD). In terms of bone and joint health, SAM-e is also used to treat osteoarthritis, reducing symptoms by inhibiting cartilage degeneration and promoting cartilage repair.
Methionine, the precursor of S-adenosylmethionine, is abundant in many protein foods, but S-adenosylmethionine is not found in foods.
SAM-e is difficult to obtain through dietary changes. You can increase SAM-e in your body by taking supplements. SAM-e can be taken orally, intramuscularly or intravenously.
SAM-e is often available in supplement form to treat specific conditions or for health care purposes. Supplement dosage and frequency should be determined based on an individual's health condition, treatment goals, and physician recommendations. Before taking SAM-e long-term, you should consult a doctor or nutrition expert to evaluate potential risks and determine appropriate dosage.
SAM-e is generally safe for the liver and has been shown to be protective against the liver in some studies. For example, it increases glutathione levels in liver cells, aiding in antioxidant and detoxification processes. However, for some individuals, especially those who have liver disease or are taking medications that may affect liver function, a doctor should be consulted before taking SAM-e. In some cases, taking too much without medical advice may put a strain on the liver.
[1] Ullah H, Khan A, Rengasamy KRR, Di Minno A, Sacchi R, Daglia M. The Efficacy of S-Adenosyl Methionine and Probiotic Supplementation on Depression: A Synergistic Approach. Nutrients. 2022 Jul 1;14(13): 2751. doi: 10.3390/nu14132751. PMID: 35807931; PMCID: PMC9268496.
[2] Li M L, Cao S Y, Qu J, et al. S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency[J]. Development, 2023, 150(20): dev201135.
[3] Giangrandi et al., Altern Integr Med 2016, 5:4 DOI: 10.4172/2327-5162.1000224
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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