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Nicotinamide riboside chloride (NR), as an emerging nicotinamide adenine dinucleotide (NAD+) precursor, has attracted widespread attention in the field of health and nutrition in recent years. NAD+ is a key intracellular coenzyme involved in a variety of biological processes, including energy metabolism, DNA repair, and cell signaling. With age, NAD+ levels in the body decrease, which is associated with a variety of aging-related diseases. Therefore, supplementing NAD+ precursors has become a potential strategy for delaying aging and improving health.
NR, as a NAD+ precursor, increases intracellular NAD+ levels by providing a direct precursor of NAD+. NAD+ is a coenzyme for a variety of important enzymes in cells, including poly (ADP-ribose) polymerases (PARPs), cyclic ADP-ribose synthases, and deacetylases (sirtuins). These enzymes play a central role in DNA repair, cellular stress response, and gene expression regulation. With age, the decline in NAD+ levels may lead to a decrease in the activity of these enzymes, which in turn affects cell function and health.
According to a recent randomized, double-blind, placebo-controlled clinical trial, long-term use of NR showed good safety and metabolic effects. The study found that different doses of NR (100, 300 and 1000 mg) were able to significantly increase whole blood NAD+ levels in a dose-dependent manner, and this increase was maintained throughout the 8-week study period. Importantly, NR intake did not cause any serious adverse events, including flushing, increased low-density lipoprotein cholesterol levels, or disturbances in 1-carbon metabolism. These data support the development of NR as a safe NAD+ precursor supplement.
In Europe, the safety of NR as a novel food has been evaluated by the European Food Safety Authority (EFSA). EFSA concluded that NR is likely to be safe for healthy adults, and EFSA also confirmed that NR is a bioavailable source of nicotinamide.
With further research on the role of NAD+ in health and aging, NR has the potential to become an important supplement to improve public health and slow the aging process. However, consumers should consult a medical professional before using any supplement to ensure its safety and suitability. As more studies and clinical trials are conducted, we will hopefully have a more complete understanding of the benefits of NR and the best use strategies.
[1] Conze D, Brenner C, Kruger C L. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults[J]. Scientific reports, 2019, 9(1): 9772.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.
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