How does S-acetyl-L-glutathione work for liver health?

 

S-Acetyl-L-Glutathione (SAG) is an important endogenous antioxidant found in various human cells. It plays a role in cellular health, especially in liver function and detoxification.

SAG plays multiple roles in the body's detoxification process and immune response. It is involved in eliminating toxic compounds that may accumulate inside cells, thereby helping to regulate inflammatory responses to fight infection and disease. As a hepatoprotectant, SAG has shown potential in preventing oxidative liver damage in dogs, indicating its wide applicability in different species.

1. Antioxidant effect

The antioxidant potential of SAG has been well demonstrated in in vitro and in vivo studies. It exhibits dose-dependent antioxidant properties, indicating its potential for application in the medical field. When SAG is combined with other natural antioxidants such as silymarin and vitamin E, its antioxidant capacity is further enhanced.

2. Synergistic effect

When used in combination with silymarin and vitamin E, SAG exhibits a synergistic antioxidant effect that exceeds the effects of each individual component. This synergistic effect is particularly promising for medical intervention as it suggests a potential therapeutic avenue for mitigating cytotoxicity caused by oxidative stress.

3. Clinical Studies

Clinical studies have further confirmed the benefits of SAG. Two recent in vivo studies tested the effects of supplements containing SAG, silymarin, and other antioxidant ingredients such as vitamin E in healthy dogs and dogs with liver disease. These studies demonstrated a significant increase in glutathione peroxidase (GPX) levels in healthy dogs, while in dogs with liver disease, the supplement showed a hepatoprotective effect and significantly increased erythrocyte GSH levels.

S-Acetyl-L-Glutathione is important in liver health as a potent antioxidant. Its ability to modulate inflammation, combat oxidative stress, and protect the liver from damage makes SAG a valuable ingredient in medical and veterinary applications. As research continues to deepen, the potential therapeutic use of SAG in mitigating cytotoxicity and supporting liver health remains an exciting area of research.

References:

[1] Lonigro N, Mohammed Z R, Perondi F, et al. Antioxidant Effect of a Combination of S-Acetyl-L-Glutathione, Vitamin E, Silybum Marianum on Hepatic Cells under Oxidative Stress: An In Vitro Study[J]. Journal of Pharmacy and Nutrition Sciences, 2024, 14: 1-7.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

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