How does Citicoline work with other ingredients?

 

Citicoline is a naturally occurring compound in the human body that is primarily involved in the synthesis of phosphatidylcholine, an important component of nerve cell membranes.

Citicoline exerts neuroprotective and anti-inflammatory effects through a variety of mechanisms, including stabilizing cell membranes, inhibiting inflammatory signaling pathways (such as NF-κB), reducing oxidative stress, and regulating microglial activity.

1. Anti-inflammatory mechanism of Citicoline:

Citicoline can inhibit the activation of NF-κB and reduce the production of proinflammatory cytokines (such as TNF-α, IL-1β, IL-6).

It reduces oxidative stress damage to nerve cells by enhancing the activity of antioxidant enzymes (such as SOD, GPx).

Citicoline can regulate the activity of microglial cells to prevent neurotoxicity caused by their overactivation.

It can also reduce the ability of peripheral immune cells to enter the central nervous system by reducing the expression of adhesion molecules (such as ICAM-1 and VCAM-1).

2. Neuroprotective effect of citicoline:

In animal models of ischemic stroke and traumatic brain injury, citicoline can reduce brain edema, reduce neuronal damage, and improve neurological dysfunction.

In Alzheimer's disease and Parkinson's disease models, citicoline improves cognitive and motor functions by reducing neuroinflammation and oxidative stress.

3. Synergistic application of citicoline with other nutrients

Recently, researchers have explored a new combination application, including citicoline, green tea, saffron, and resveratrol. The study first proved that the combination of citicoline, green tea, saffron, and resveratrol has a significant protective effect on oxidative stress-induced cognitive decline in an in vitro model. The combination works through multiple mechanisms, including enhancing antioxidant defense, reducing inflammation, promoting the production of neurotrophic factors, and reducing the levels of neurodegenerative markers.

As we age, the brain's antioxidant defense system becomes unbalanced, leading to increased oxidative stress, which damages DNA, proteins, and lipids, triggers inflammatory responses, and leads to cognitive dysfunction. The mechanism of action and application prospects of citicoline in neuroinflammation provide a new direction for the development of new neuroprotective nutritional supplements.

References:

[1] Mulè S, Ferrari S, Rosso G, et al. The Combined Effect of Green Tea, Saffron, Resveratrol, and Citicoline against Neurodegeneration Induced by Oxidative Stress in an In Vitro Model of Cognitive Decline[J]. Oxidative Medicine and Cellular Longevity, 2024, 2024(1): 7465045.

[2] Cavalu S, Saber S, Ramadan A, et al. Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders[J]. The FASEB Journal, 2024, 38(17): e70030.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

by GSHWORLD

GSHWORLD is China Biological API Manufacturer. China Glutathione Supplements powder suppliers & best Glutathione benefits raw material Factory.