Does nmn work？

by: GSHWORLD time: 2024-09-25 classify: Product News

With the continuous deepening of scientific research, people's pursuit of health and longevity has become more and more urgent. NMN is the direct precursor of NAD+ (nicotinamide adenine dinucleotide) in the human body, and NAD+ is an important coenzyme in cells and participates in many physiological and metabolic reactions. Today, let’s talk about whether NMN is really effective and what its scientific basis is.

1. Metabolic effects

In terms of metabolism, NMN exhibits positive effects. Research shows that NMN can increase NAD+ levels in the blood, which is helpful for improving muscle function, enhancing insulin sensitivity, and regulating blood pressure and blood sugar. Especially for individuals with excessive postprandial insulin secretion, NMN can attenuate postprandial hyperinsulinemia, which has potential implications for the prevention of coronary artery disease.

Metabolic effects

2. Anti-aging effect

NMN, as the precursor of NAD+, shows anti-aging potential by increasing NAD+ levels in the body. Research shows that NMN can improve a variety of diseases associated with aging, including cognitive decline, cancer, metabolic diseases, osteoporosis and physical frailty.

3. Clinical trials

Multiple clinical trials have shown that NMN supplements can significantly increase NAD+ levels in the blood. These trials also showed that NMN had some positive effects on improving muscle function, insulin sensitivity, blood pressure, and blood sugar levels. These findings provide preliminary evidence for the potential anti-aging effects of NMN.

Anti-aging effect

4. Safety and Tolerability

First of all, the security of NMN cannot be ignored. According to a Japanese clinical study, NMN supplementation at 250 mg per day for 8 weeks was well tolerated in healthy middle-aged Japanese men, with no serious adverse events.

Taken together, NMN, as a supplement, shows certain effects in increasing NAD+ levels and improving metabolic health. However, current clinical trials are relatively small and there is a lack of long-term, large-scale studies to verify their effectiveness and safety. Future research is needed to overcome the limitations of the current study and explore the long-term effects of NMN in different populations and conditions.

References:

[1] Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. Adv Nutr. 2023 Nov;14(6):1416- 1435. doi: 10.1016/j.advnut.2023.08.008. Epub 2023 Aug 22. PMID: 37619764; PMCID: PMC10721522.

[2] Yamaguchi S, Irie J, Mitsuishi M, et al. Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men[J]. Endocrine journal, 2024, 71(2): 153-169.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

Tag: NMN