Characteristics and application fields of S-acetyl glutathione

by: GSHWORLD time: 2025-02-27 classify: Product News

S-Acetyl-L-Glutathione (SAG), as an important glutathione precursor, has received widespread attention in the field of food and dietary supplements in recent years. Glutathione (GSH) is a key antioxidant in the human body and is involved in a variety of physiological functions, including antioxidant defense, immune regulation and detoxification.

Product Features

1. High stability

SAG is a derivative of glutathione, which is modified by acetylation to make it more stable in the gastrointestinal tract and not easily decomposed. This characteristic allows SAG to be more effectively absorbed by the human body and converted into active glutathione (GSH) in cells.

2. Strong antioxidant capacity

SAG has strong antioxidant capacity, which can neutralize free radicals and reduce the damage of oxidative stress to cells. Studies have shown that SAG exhibits dose-dependent antioxidant effects in both in vitro and in vivo experiments.

3. Significant synergistic effect

When SAG is used in combination with other antioxidant ingredients (such as silymarin and vitamin E), it shows a stronger synergistic antioxidant effect. This combination performs well in reducing oxidative stress and protecting cell health.

Application areas

1. Health field

SAG has a significant protective effect on liver health, can reduce oxidative stress and inflammatory response, and optimize liver detoxification function. In addition, SAG has been shown to enhance immune function and support cell health.

2. Food field

SAG can be used as a base material for functional foods and added to beverages, candies, dairy products and pasta products as a nutritional enhancer. Its stable properties and odor-free characteristics make it have a wide range of application prospects in the food industry.

3. Cosmetic field

SAG has antioxidant, whitening, anti-aging and other effects. It can be added to skin care products to help improve skin condition, reduce wrinkles and increase skin elasticity.

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Safety

Safety is a key factor in whether any ingredient in food and dietary supplements can be widely used. The safety of SAG has been fully verified through multiple toxicology studies. SAG did not show any genotoxic or mutagenic activity in in vitro bacterial reverse mutation and micronucleus tests. In a 13-week repeated dose toxicity study, SAG did not cause any neurobehavioral changes or adverse effects on hematology, blood biochemistry, urinalysis and other indicators at the highest dose of 1500 mg/kg/day. These findings indicate that SAG is safe for use in food and dietary supplements.

Clinical Research and Application

Clinical studies have shown that SAG exhibits significant liver protection effects in animal experiments, significantly increasing glutathione peroxidase (GPx) levels and improving liver health. These findings indicate that SAG has potential application value in the prevention and treatment of oxidative stress-related diseases.

Anhui Gute Bio's S-acetyl glutathione is a high-quality antioxidant with good stability and bioavailability, suitable for multiple fields such as health, food and cosmetics. Its significant effects in anti-oxidation, liver protection and immune support make it a highly competitive product on the market.

References:

[1] Camillerapp C, Mayfield D B, Papineni S, et al. Safety Assessment of S-Acetyl Glutathione for Use in Foods and Dietary Supplements[J]. Food and Chemical Toxicology, 2025: 115279.

[2] [2] Lonigro N, Mohammed Z R, Perondi F, et al. Antioxidant Effect of a Combination of S-Acetyl-L-Glutathione, Vitamin E, Silybum Marianum on Hepatic Cells under Oxidative Stress: An In Vitro Study[J]. Journal of Pharmacy and Nutrition Sciences, 2024, 14: 1-7.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.

Tag: Acetyl Glutathione, SAG , GSH