Glutathione (GSH) is a naturally occurring antioxidant produced by the liver and central nervous system that is said to help metabolize toxins, break down free radicals, support immune function, and more. Researchers have explored its potential use for diseases such as cystic fibrosis, chemotherapy-related toxicity, and Parkinson’s disease. There is currently insufficient scientific evidence to…
What are important functions and effects of citicoline? Citicoline, or CDP-choline, is an important biochemical substance. In our bodies, it is widely used to synthesize phospholipids, especially the main components of cell membranes. Citicoline has a wide range of functions, especially in the health of the nervous system and cognitive function plays an important role….
Research points This article investigates the metabolic mechanism of glutathione (GSH) as an antioxidant in Corynebacterium glutamicum, and constructs an efficient glutathione producing strain through metabolic engineering and fermentation optimization strategies. Research has found that by modifying glutathione synthase (GshF), knocking out genes related to hydrogen sulfide production and glutathione degradation, and combining with overexpression…
Introduction to glutathione Glutathione (GSH) is a non-essential amino acid that is widely present in the body and plays an important role in maintaining the normal function of cells. It is not only an important antioxidant, but also a compound involved in a variety of biochemical reactions. Source of glutathione Glutathione is mainly found in…
To investigate the role of NMN in blood vessel formation, a joint study was conducted by Harvard University, Princeton University and Swiss research institutions. The decline of blood vessel function, especially the deterioration of blood vessels that flow through the body, is closely related to the aging process. Research process and discovery 1. Subjects and…
Ischemic injury is the number one cause of death and disease in the world, including the United States and China, and vascular endothelial growth factor (VEGF) gene therapy holds promise for patients with ischemic injury. However, the high immunogenicity of traditional viral vectors (such as adeno-associated virus AAV) and the low expression efficiency of lipid…
Abstract Recently, Zhong Cheng/Xin Bo team of Tianjin University of Science and Technology College of Bioengineering published an article in the Journal of Agricultural and Food Chemistry: Tandem GGDEF-EAL domain proteins pleiotropically modulates c-di-GMP metabolism enrolled in bacterial cellulose Biosynthesis (https://doi.org/10.1021/acs.jafc.4c07301), which reported GGDEF – EAL tandem structure domain protein c – di – GMP…
When a metabolic function is “leaky” to the community (i.e., partially available to other species), microbes can save energy by stopping production of that function and relying on other species to perform it. Metabolic dependence in organisms can be formed by the loss of certain easily replaceable functions, such as the active deletion of certain…
01 Abstract Following the work on constructing the highest L-threonine yield from polyploid Escherichia coli [LiangQuanfeng Shanshan/Qi Qingsheng group Adv Sci | Created artificial polyploid Escherichia coli and applied to threonine synthesis] published in the leading journal Advanced Science, Liang Quanfeng/Qi Qingsheng team of the State Key Laboratory of Microbial Technology of Shandong University published…
Japanese scientists have found that NMN supplementation can prevent age-related hearing loss in mice. NMN inhibits age-related hearing loss Mice naturally lose their hearing as they age, just like humans do. To confirm this, we compared the hearing of 25-week-old mice (about 30 human years) with that of 12-week-old mice (about 21 human years). The…