Citicoline is a neuroprotective agent

Citicoline sodium is widely used as a neuroprotective agent

Citicoline is a neuroprotective agent Citicoline is one of the common drugs used in the treatment of central nervous system. It is often used in the treatment of cerebral infarction, cerebral insufficiency, cerebral atrophy and other diseases, especially for patients with cerebral infarction. The essence of citicoline is an activator of energy metabolism, which plays…

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Glutathione

Glutathione is a natural antioxidant

Glutathione (GSH) is a naturally occurring antioxidant produced by the liver and central nervous system that is said to help metabolize toxins, break down free radicals, support immune function, and more. Researchers have explored its potential use for diseases such as cystic fibrosis, chemotherapy-related toxicity, and Parkinson’s disease. There is currently insufficient scientific evidence to…

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Maintaining redox homeostasis to regulate efficient glutathione metabolism in Corynebacterium glutamicum

Maintaining redox homeostasis to regulate efficient glutathione metabolism in Corynebacterium glutamicum

Research points This article investigates the metabolic mechanism of glutathione (GSH) as an antioxidant in Corynebacterium glutamicum, and constructs an efficient glutathione producing strain through metabolic engineering and fermentation optimization strategies. Research has found that by modifying glutathione synthase (GshF), knocking out genes related to hydrogen sulfide production and glutathione degradation, and combining with overexpression…

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Extracellular vesicle-mediated VEGF-A mRNA delivery rescues ischaemic injury with low immunogenicity

A novel gene therapy for ischemic heart disease based on engineered external vesicles with high efficiency and low immunogenicity

Ischemic injury is the number one cause of death and disease in the world, including the United States and China, and vascular endothelial growth factor (VEGF) gene therapy holds promise for patients with ischemic injury. However, the high immunogenicity of traditional viral vectors (such as adeno-associated virus AAV) and the low expression efficiency of lipid…

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Tandem GGDEF-EAL Domain Proteins Pleiotropically Modulatec-di-GMP Metabolism Enrolled in Bacterial Cellulose Biosynthesis

Tandem GGDEF-EAL domain proteins promote bacterial cellulose synthesis

Abstract Recently, Zhong Cheng/Xin Bo team of Tianjin University of Science and Technology College of Bioengineering published an article in the Journal of Agricultural and Food Chemistry: Tandem GGDEF-EAL domain proteins pleiotropically modulates c-di-GMP metabolism enrolled in bacterial cellulose Biosynthesis (https://doi.org/10.1021/acs.jafc.4c07301), which reported GGDEF – EAL tandem structure domain protein c – di – GMP…

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