For people at risk of cardiovascular diseases, regular physical examination, healthy living habits, and appropriate supplementation of anti-aging nutrients represented by NMN have a positive effect on delaying the occurrence of cardiovascular diseases.
The heart is like an indefatigable “engine” in the body, providing power for life activities day and night, and its health status directly affects our quality of life and length of life.
In the fast pace of modern life, the heart is facing many challenges.
About 2.6 million people die of cardiovascular and cerebrovascular diseases each year in China, the second highest death toll in the world.
With the aging of the population, the prevalence of cardiovascular disease is also increasing, becoming the “first killer” in China and even in the world.
How to protect yourself from the threat of this disease through scientific prevention?
Supplement NMN and improve NAD+ level
The pathogenesis of cardiovascular diseases includes atherosclerosis, hypertension, myocardial ischemia, heart failure and so on.
In recent years, studies have shown that NMN (nicotinamide mononucleotide) can protect the cardiovascular system in many aspects by increasing the level of NAD+, showing potential therapeutic and preventive effects of cardiovascular diseases.
1. Improve vascular endothelial function
The dysfunction of vascular endothelial cells is one of the main pathological features of cardiovascular diseases such as atherosclerosis and hypertension.
By increasing the level of NAD+, NMN activates the longevity protein SIRT1 (deacetylase) and other pathways related to endothelial protection, which helps to maintain the integrity of vascular endothelial cells and reduce endothelial damage.
A study published in Cell Metabolism suggests that the restoration of NAD+ levels can significantly improve vascular endothelial dysfunction due to aging, thereby reducing the risk of cardiovascular disease.
At the same time, animal experiments showed that NMN could reduce vascular inflammation and improve vascular endothelial diastolic function by activating SIRT1.
2. Antioxidant and anti-inflammatory effects
The occurrence of cardiovascular disease is often accompanied by oxidative stress and chronic inflammation, and these factors can accelerate arteriosclerosis and vascular damage.
NMN can enhance the level of NAD+, enhance the activity of antioxidant enzymes, inhibit the expression of inflammatory factors, and thus slow down the progression of disease.
A study published in Nature Communications shows that NAD+ plays an important role in inhibiting free radical generation and alleviating oxidative damage, and NMN, as a direct precursor of NAD+, can effectively alleviate oxidative stress responses in the cardiovascular system.
NMN reduces the damage of chronic inflammation to blood vessels by reducing the levels of C-reactive protein and tumor necrosis factor α.
3. Promote myocardial repair and functional recovery
Myocardial ischemia and heart failure are one of the most serious manifestations of cardiovascular disease.
NMN can improve mitochondrial function by increasing the level of NAD+ in cardiomyocytes, and promote the repair and functional recovery of cardiomyocytes.
A study published in Science shows that NMN can significantly improve heart function by increasing NAD+ levels and alleviating mitochondrial dysfunction caused by myocardial ischemia.
In a mouse model of heart failure, myocardial contractility increased and oxidative stress levels significantly decreased after NMN supplementation, suggesting its potential in improving heart function.
4. Improve lipid metabolism
Abnormal lipid metabolism is one of the key factors leading to atherosclerosis.
By activating enzymes associated with lipid metabolism, such as SIRT1, NMN helps regulate cholesterol and triglyceride levels and reduces the risk of atherosclerosis.
A study published in Circulation Research found that elevated levels of NAD+ significantly improved lipid metabolism in mice, lowering serum total cholesterol and low density lipoprotein (LDL) levels.
In a mouse model of obesity with metabolic syndrome, NMN supplementation not only improved dyslipidemia, but also reduced levels of inflammatory markers.
5. Inhibit platelet aggregation and prevent thrombosis
Abnormal platelet activation and aggregation is an important step of arterial thrombosis.
By enhancing the NAD+ metabolic pathway, NMN regulates platelet function and reduces the risk of thrombosis.
A study in the journal of Thrombosis Research indicates that the recovery of NAD+ can inhibit the release of platelet-activating factor, thereby reducing the formation of blood clots.
It was found that platelet aggregation ability was significantly reduced after NMN supplementation, while blood circulation and vascular permeability were improved.
NMN can help maintain blood vessel health and reduce the risk of atherosclerosis, thereby reducing the incidence of cardiovascular disease.
NMN has a positive impact on the cardiovascular system through a variety of pathways, including enhancing cellular energy metabolism, lowering blood pressure, antioxidants, improving lipid levels, and promoting vascular endothelial cell function, fundamentally reducing the risk of cardiovascular disease.
Adjust the way of life, and actively prevent
For high-risk people with a family history of related diseases or bad lifestyle habits, they should be more concerned about their cardiovascular system, on the one hand, regularly experience and pay attention to whether they have related disease symptoms;
On the other hand, by actively adjusting your lifestyle, you can help yourself stay away from the threat of related diseases.
According to relevant guidelines and research analysis, for people who have not yet fallen ill, as long as they actively do a good job of “primary prevention” and take measures to prevent the occurrence of disease, the onset of cardiovascular disease can be delayed by ten years.
The goal of primary prevention is to prevent the occurrence of disease by promoting a healthy lifestyle and managing risk factors, thereby reducing the risk of disease in the entire population.
Research shows that more than 80% of adverse cardiovascular events can be prevented through healthy lifestyle and management of known risk factors.
In the prevention of cardiovascular disease, primary prevention usually includes the following measures:
1. Healthy diet
Reduce your risk of cardiovascular disease by eating a balanced, nutritious diet that reduces your intake of high fat, cholesterol and sugar, increases your intake of fruits, vegetables and whole grains, and makes healthy protein sources such as fish and legumes.
2. Moderate exercise
Regular moderate aerobic exercise, such as brisk walking, jogging, swimming or cycling, can enhance cardiovascular system function and reduce the risk of cardiovascular disease.
Stop smoking and limit alcohol consumption
Quitting smoking and limiting alcohol intake are important measures to prevent cardiovascular disease.
Smoking and alcohol abuse are major risk factors for cardiovascular disease, and quitting smoking and limiting alcohol consumption can significantly reduce the risk of cardiovascular disease.
3. Managing risk factors
Including control of high blood pressure, high blood sugar and high cholesterol levels, as well as weight management, control of blood pressure and blood sugar, is one of the key measures to prevent cardiovascular disease.
Through these preventive measures, can effectively reduce the risk of cardiovascular disease, delay the onset of time.
