Glutathione S-transferase: The Detoxifying Enzyme Family
Glutathione S-transferase (GST) is a family of enzymes that play a key role in the detoxification of various toxic and carcinogenic compounds in the body. GSTs catalyze the conjugation of glutathione (GSH), a tripeptide composed of glycine, cysteine, and glutamate, to electrophilic substrates, such as halogenated hydrocarbons, epoxides, aldehydes, and nitroaromatics. This reaction reduces the…