Glutathione (GSH) is a natural antioxidant that effectively helps remove free radicals from the body and inhibits melanin formation.
Glutathione inhibits melanin in three ways:
- (1) tyrosinase activity is directly inhibited by sulfhydryl chelation with tyrosinase (a key enzyme in the synthesis of melanin).
- (2) Glutathione interferes with the cellular transfer of tyrosinase to melanin precursors, which is a prerequisite for melanin synthesis.
- (3) tyrosinase inhibition is indirectly achieved through its antioxidant effect.
Glutathione inhibits melanin production through the reaction between sulfhydryl and dopa quinone (an intermediate product of melanin synthesis) to form a mercaptodopa chelate.
For oral use:
A randomized, double-blind, two-group, placebo-controlled study in a Thai population examined the effect of oral glutathione on skin melanin index in 60 healthy medical students.
Participants were randomly assigned to receive glutathione capsules at a dose of 500 mg/day in two doses, or placebo, for four weeks.
The primary endpoint of the study was a reduction in the melanin index at six different sites.
At four weeks, the melanin index in the glutathione group continued to decline at all six sites.
For local external application (washing) :
A randomized, double-blind, placebo-controlled clinical trial in 30 healthy Filipino women aged 30-50 years provided some evidence to support the efficacy of topical use of 2% GSSG (oxidized glutathione) lotions for temporary skin whitening.
Patients were randomly given glutathione as a 2% GSSG lotion or a placebo lotion twice daily for ten weeks.
GSSG is superior to reduced glutathione because reduced glutathione is unstable in aqueous solution.
GSSG is absorbed through the skin to produce glutathione. Objective evaluation of cuticle, skin smoothness, skin elasticity and wrinkle formation.
There was a statistically significant increase. Compared with placebo, glutathione had a statistically significant reduction in melanin index.
For intravenous administration:
Due to the low bioavailability of oral glutathione, intravenous glutathione is being promoted to provide the desired therapeutic level in the blood and skin and produce “instant” skin lightening.
Interestingly, intravenous glutathione has been used for years, but not even a single clinical trial has evaluated its efficacy.
Manufacturers of intravenous glutathione recommend a dose of 600-1200 mg for skin whitening, given once or twice a week.
Intravenous administration is expected to achieve 100% bioavailability of glutathione, which is much higher than oral administration.
No research supports this hypothesis. Although intravenous glutathione provides a higher therapeutic dose and enhances its efficacy, it should not be tried due to the potential for excessive toxicity.
In SUMMARY:
Glutathione can whiten! But try to use both oral and topical. Oral glutathione to find regular nutritional supplements according to the effective dose of eating.
For external use, look for regular products containing oxidized glutathione at concentrations greater than 2%.
About
Anhui GSH Bio-Technology Co.,LTD. has gathered overseas returnees, university professors, industry experts and other technical teams in many fields such as enzyme engineering, fermentation engineering, molecular biology, AI technology, chemistry, materials science, pharmacy and engineering.
Anhui GSH Bio-Technology Co.,LTD. is a global pioneer of enzyme-catalyzed coupled ATP regeneration technology, with a number of independent intellectual property rights, has been granted 6 national invention patents, another under review of more than 10 invention patents, 2 PCT patents.
The technical application of enzymatic production of pharmaceutical raw materials of Anhui GSH Bio-Technology Co.,LTD. subverts the traditional fermentation method, truly achieves environmental protection and energy saving, green production, and occupies a leading position in the market of characteristic raw materials.
Anhui GSH Bio-Technology Co.,LTD. The company’s main products are glutathione (GSH), creatine phosphate (CP), β-nicotinamide mononucleotide (NMN) and adenosine methionine (SAM) and other raw materials, of which glutathione, β-nicotinamide mononucleotide market share ranked top three in China, products are exported to Europe, America, South Korea, India and other parts of the world.
