Based on the known beneficial effects of exercise on obesity metabolism, scientists found that exercise improves metabolic function by increasing NAD+ levels to upregulate mitochondrial activity. NMN
In April 2023, the research published online in “Biochemistry and Biophysics Reports” by the Graduate School of Comprehensive Pharmacy and Nutritional Sciences, Shizuoka University, Japan once again confirmed the fat-reducing effect of NMN:
NMN can significantly reduce the amount of subcutaneous fat and the size of fat cells, and The study also explored the fat-reducing mechanism of β-Nicotinamide Mononucleotide in detail.
We know that NAD+ (nicotinamide adenine dinucleotide) levels in the human body will decrease with aging. In fact, many studies have found that NAD+ levels will also decrease with nutritional conditions (such as obesity) reduce.
Using mice, the researchers found that intracellular NAD+ levels decrease with obesity in tissues, including adipose tissue, skeletal muscle, liver, and hypothalamus.
As an important coenzyme involved in various energy metabolism pathways, as the level of NAD+ decreases, various metabolic disorders will further develop. This makes obesity closely related to the occurrence and development of metabolic diseases, and has become an important risk factor for type 2 diabetes, metabolic syndrome, hypertension, and cardiovascular and cerebrovascular diseases.
Many studies have found that β-Nicotinamide Mononucleotide, the precursor of NAD+, can help improve metabolic function and help weight management.
In 2012, Dr. Yoshino J, Department of Developmental Biology, Washington University School of Medicine, and others found that intraperitoneal injection of NMN improved glucose tolerance and lipid distribution in type 2 diabetic mice by increasing NAD+ levels.
Actual Weight Loss Studies Taking NMN:
In the 28h fasting method, the weight loss effect of NMN supplementation was compared with dry break (no supplements, only drinking water and no food) and supplementing β-Nicotinamide Mononucleotide fasting (adding 2 NMN capsules a day except drinking water) Even better, significant changes in body weight, blood sugar and blood ketones.
After taking β-Nicotinamide Mononucleotide, body weight and blood sugar decreased significantly, and blood ketone levels increased significantly. Ketone bodies are the products of fat breakdown. When the ketone bodies in the blood increase, it means that the fat breakdown increases.
Intake of NMN not only has a better weight loss effect, but also because β-Nicotinamide Mononucleotide can improve the body’s metabolism, the body’s chills caused by weight loss and fasting will also be alleviated or disappeared due to NMN’s increased metabolism.
Fasting is a matter that requires willpower, the process is difficult, and it is easy for people to collapse and give up. However, using NMN during fasting will speed up metabolism, sleep well, and be energetic, and the process is not painful.
