The relationship between NAD+ (nicotinamide adenine dinucleotide, referred to as coenzyme I) and health has been a hot topic of research by scientists around the world.
A newly completed clinical study led by Professor Mericskay Mathias of the University of Paris Sacre reveals:
Older patients with heart failure had significantly lower levels of NAD+ in their blood compared to healthy middle-aged people.
The study, published in the international journal of Experimental Gerontology, supports previous research showing that NAD improves heart function.
With the deepening of the research of aging by scientists around the world, researchers have found that the change of NAD+ levels in human tissues with age may be the culprit of various chronic diseases or degenerative diseases.
NAD+ is an important coenzyme involved in the regulation of energy metabolism in cells. In young and middle-aged people, the synthesis and consumption of NAD+ maintain a dynamic balance.
In the elderly population, the amount of NAD+ synthesis is reduced, the consumption is increasing, and the total amount of NAD+ is constantly reduced, which eventually leads to organ dysfunction or even disorder.
The clinical trial, led by Professor Mericskay Mathias, involved 151 healthy volunteers with an average age of 41 and 19 patients with heart failure with an average age of 85.
The researchers took whole blood samples from all participants and analyzed differences in NAD levels in their samples to identify potential heart failure detection indicators or therapeutic targets.
The results showed that:
Blood NAD+ concentration was significantly lower in elderly patients with heart failure than in healthy volunteers (mean concentration: 23.4umol/L in healthy volunteers and 20.7umol/L in patients with heart failure).
Before interventional treatment, the blood NAD concentration of elderly patients with heart failure will remain at a low level for a long time.
The blood NAD+ concentration of male healthy volunteers decreased with age, while the NAD+ concentration of female volunteers remained stable.
“Our study demonstrates the fact that NAD+ levels are reduced in the blood of elderly patients with heart failure, regardless of age, sex or other complications.”
Professor Mericskay Mathias said, “However, due to the limited experimental sample, the results of this study inevitably have some statistical errors.
If more studies confirm that the decrease of NAD in the tissue is the cause of the decrease of NAD+ in the blood, which induces heart failure, then supplementing the NAD+ level in the tissue with NAD+ and its synthetic intermediates may be a powerful means to prevent heart failure.”
How to scientifically supplement NAD+?
Given the anti-aging effectiveness of NAD+, it is now becoming a common therapy.
Although there are many forms of supplementation, they are not all equally effective.
After years of research, NADclinic and its research team have led the way in introducing a breakthrough exogenous technology for NAD+ supplementation, which can be 100% absorbed and utilized by the human body, using liposome encapsulation and endocytosis to activate NAMPT’s enzyme mediations, not only providing sufficient NAD+ molecules directly, but also improving the efficiency of NAD+ recycling in the body.
After receiving NAD+ supplementation, the following effects can be clearly seen:
- 1, sleep efficiency is greatly improved, improve insomnia, and a series of uncomfortable symptoms caused by sleep.
- 2, energy is improved, fatigue can also be greatly relieved.
- 3, the metabolism is accelerated, people become significantly thinner.
- 4, the immune system is strengthened, not easy to get sick.
- 5, the body’s signs of aging have been delayed for a long time
However, the current market with the NAD, NMN flag of the product is mixed, consumers are difficult to distinguish, and ultimately wasted money.
Leading experts from, a pioneer in molecular medicine, formed a top scientific research team and, after years of research, finally found the original NAD+ exogenous direct supplement technology.
① Promote the complete absorption of NAD+
NAD+ molecules were encapsulated by multi-layer polycystic liposomes to enable them to successfully reach the small intestine against gastric acid consumption.
Liposomes are attached with special phosphate molecular structures, which can bind to receptors on the surface of small intestine cells, so that the liposomes can successfully penetrate the cell membrane barrier and enter the cell interior, releasing NAD+ molecules.
② Open up the internal circulation of NAD+
Any NAD+ precursor converted to NAD+ and involved in anti-aging and gene repair work will be converted to NAM (niacinamide).
And that NAM, converted by an enzyme called NAMPT, can turn into NAN, and then regenerate NAD+, and so on, and this pathway is the internal circulation of NAD+.
While directly providing sufficient NAD+ molecules, NAD+, NA, and NAM can maintain a certain proportion of the three components into the cell, which can activate the enzyme mediation of NAMPT, so that NAD+ can be orderly synthesized in the body and form an internal circulation state.
