Can NMN which is consumed by the wealthy really resist aging?

Can NMN, which is being eaten by the wealthy circle, really resist aging? It’s the most comprehensive analysis in history!

I don’t know since when, anti-aging has become the main focus of maintenance costs for girls. Images of 40 years old being like 20 years old have been hyped up, and a certain book platform has sprung up with a large number of anti-aging strategies. Various anti-aging ingredients have been wildly promoted, and it seems that it is not difficult to regain youthful vitality.

At the peak of the anti-aging trend, NMN also emerged and suddenly entered the center of the anti-aging market. How magical is it?

Today we will talk about the anti-aging star ingredient – NMN.

1、 What is NMN? Nicotinamide mononucleotide (NMN) is a naturally occurring molecule found in every living cell of all life forms. At the molecular level, it belongs to a class of molecules called nucleotides, which are components of RNA and DNA. Structurally, NMN consists of three main chemical groups: phosphate group, ribose group, and nicotinamide base (see figure above). NMN is directly converted to nicotine adenosine dinucleotide (NAD+), thereby increasing the level of NAD+. In 2020, it was referred to as the “first year of the NMN revolution” by anti-aging industry insiders. Why do you say that? Because during this year, NMN achieved a qualitative development from scratch and quickly gained popularity. It is understood that in 2020, nearly 25% of the research literature on the entire anti-aging industry was related to NMN. Not only that, the “concept stocks” associated with NMN have also become the object of investment for thousands of investors. There are also rumors that gambling kings rely on it to survive. The authenticity of these messages is unknown, but it is sufficient to indicate that NMN’s anti-aging effect has been recognized by many people.

Since when did NMN become a “universal” anti-aging ingredient, sought after by scientists and consumers? This starts with a research report. 2、 In March 2020, a professor from the National University of Singapore published an academic research report in top anti-aging journals. This report provides a comprehensive and detailed inventory of the “star products” in the anti-aging industry, also known as NMN. NMN is an important branch of dietary supplements that can play a positive role in combating aging. He used animal experiments to determine the genetic activity of NMN substances, indicating that NMN can help users solve thorny aging problems, effectively repairing endogenous aging, improving skin dullness and sagging, and gradually repairing dark circles and eye bags, returning the skin to a delicate and tight state. Even more miraculously, NMN can accelerate cell repair by increasing NAD+levels, restoring a youthful state from the inside out, truly achieving “reverse aging”.

The professor proposed the concept of NMN’s “disease treatment theory”. He believes that long-term use of NMN by users can effectively reduce the damage of aging to nerve cells, thereby reducing the probability of developing “Alzheimer’s disease”. At the same time, it can repair damaged DNA from within, help users restore memory, accelerate metabolism, and thus avoid fat accumulation obesity. Since this research report, authoritative international journals such as CELL, NATURE, and SCIENCE have also confirmed the inhibitory effect of NMN on aging in the body from multiple perspectives. Professor David Sinclair’s experimental study found that after taking NMN for one week, mice aged 70 in humans returned to their 20 year old state and their lifespan was extended by 20%. Anti aging has always been a sensitive term in the skincare industry, and words such as “reverse aging” and “turning the clock” make people doubt their efficacy but feel ready to move on. But NMN has demonstrated market dominance as a “dark horse” product in various aspects such as anti-aging and disease resistance. With these experimental evidence, I would like to try its magical effects

3、 The Importance of NMN Improving NAD+

NAD+is the most abundant molecule after water and is essential for life. NAD+is a coenzyme – a “helper” molecule required for enzymes to function. Enzymes are a special type of protein that can accelerate chemical reactions. For example, without enzymes, some biological reactions would take 2.3 billion years to complete. Therefore, without enzymes, life cannot exist.

Importantly, with age and chronic diseases such as obesity, cardiovascular disease, neurodegenerative disease, and sarcopenia (age-related muscle atrophy), NAD+decreases. Therefore, in this case, using NAD+precursors such as NMN to restore NAD+levels can potentially alleviate the adverse effects of aging and even prevent or reverse chronic diseases. Currently, increasing scientific evidence supports the enhancement of NAD+’s anti-aging and longevity effects in animal models and humans.

4、 NAD+Activate Sirtuins

NAD+is a key enzyme fuel called sirtuins. Sirtuins are known as “guardians of cells” because they play a positive role in repairing DNA and supporting the health of our mitochondria. Mitochondria are called the power stations of cells because they produce cellular energy called ATP. Unhealthy mitochondria produce less ATP, which can lead to cell death. Due to excessive DNA damage that can also lead to cell death, sirtuins promote cell survival by repairing DNA and maintaining the original state of mitochondria.

As David Sinclair, a geneticist and NAD+researcher at Harvard University, puts it, as we age, we lose NAD+, and the resulting decrease in sirtuin activity is considered the main cause of disease in our body in old age rather than young. He believes that increasing NAD+levels, including NMN, may slow down or reverse certain aging processes during aging.

In addition to NMN, polyphenols – plant molecules that promote longevity, exercise, and calorie restriction – consuming fewer calories without malnutrition can also increase NAD+levels and activate sirtuins. In addition to increasing cell survival and protecting DNA (genomic stability), sirtuins provide many benefits. Sirtuins can prevent diabetes and fatty liver by improving insulin secretion of pancreas, promoting fat metabolism of liver, and improving glucose production of liver. Sirtuins can also protect against muscle atrophy, neurodegeneration, and the increase of adipose tissue.

5、 Function of NAD+as mitochondrial coenzyme

NAD+plays a particularly active role in metabolic processes, such as glycolysis, TCA cycle (AKA KREBS cycle or citric acid cycle), and electron transfer chains that occur in mitochondria, which are pathways for us to obtain cellular energy.

As a ligand, NAD+binds to enzymes and transfers electrons between molecules. Electrons are the atomic basis of cellular energy, acting by transferring them from one molecule to the next NAD+through cellular mechanisms similar to battery charging. When electrons are consumed to provide energy, the battery is depleted. If there is no boost, these electrons cannot return to their starting point. In cells, NAD+acts as a booster. In this way, NAD+can reduce or increase enzyme activity, gene expression, and cell signal transduction.

6、 NAD+helps control DNA damage

As organisms age, they accumulate DNA damage due to environmental factors such as radiation, pollution, and inaccurate DNA replication. According to current aging theory, the accumulation of DNA damage is the main cause of aging. Almost all cells contain a “molecular mechanism” for repairing this damage. This machine consumes NAD+and energy molecules. Therefore, excessive DNA damage can consume valuable cellular resources.

An important DNA repair protein, PARP poly adenosine diphosphate ribose polymerase (Poly (ADP ribose) polymerase), relies on NAD+to function. The level of NAD+in elderly people decreases. The accumulation of DNA damage during normal aging leads to an increase in PARP, resulting in a decrease in NAD+concentration. Any further DNA damage in mitochondria will exacerbate this loss.

7、 Why should we care about NAD+

Since the discovery of NAD+in 1906, this molecule has been on scientists’ radar because it is abundant in the human body and plays a crucial role in maintaining the molecular pathways of our body’s operation. In animal research, increasing the level of NAD+in the body has shown promising results in research fields such as metabolism and age-related diseases, and even demonstrated some anti-aging properties. Age related diseases, such as diabetes, cardiovascular disease, neurodegeneration and the overall decline of the immune system.

NAD+helps Sir tui ns maintain genomic integrity and promote DNA repair. Just like a car cannot run without fuel, the activation of sirtuins requires NAD+. Animal research results indicate that increasing the level of NAD+in the body can activate sirtuins and prolong the lifespan of yeast, worms, and mice. Although animal studies have shown promising results in anti-aging performance, scientists are still studying how these results can be transformed into humans.

1.Help combat metabolic disorders

NAD+is one of the key factors in maintaining healthy mitochondrial function and stable energy output. Aging and a high-fat diet can lower the level of NAD+in the body. Research has shown that taking American W+NMN (telomere tower) can reduce diet related and age related weight gain in mice, and improve their exercise ability, even in elderly mice. Other studies have even reversed the diabetes effect of female mice, showing new strategies for combating metabolic disorders (such as obesity).

2.Improve cardiac function

Providing NAD+levels can protect the heart and improve heart function. High blood pressure can cause heart enlargement and arterial blockage, leading to stroke. Chinese NMN (GSHWORLD) supplements the NAD+levels in the heart to prevent heart damage caused by a lack of blood flow. Other studies have shown that GSHWORLD NMN can protect mice from the effects of abnormal cardiac enlargement.

3.Resist Neurode generation

In mice with Alzheimer’s disease, increasing NAD+levels can reduce protein accumulation, which disrupts cellular communication in the brain. Increasing cognitive function can also protect brain cells from death by increasing NAD+levels when there is insufficient blood supply to the brain. Many studies conducted in animal models aim to assist in healthy aging of the brain, resist neurogenesis, and improve memory.

4.Improve the immune system

As adults age, the immune system decreases, making it easier for people to get sick and harder to maintain health. Recovered from diseases, such as seasonal influenza, and even COVID-19. Recent studies have shown that NAD+levels play an important role in regulating inflammation and cell survival during immune response and aging processes. This study emphasizes the therapeutic potential of Chinese NMN (GSHWORLD) 32000 for immune dysfunction.

5.Why choose China NMN (GSHWORLD):

99.9% purity NMN does not contain components other than NMN, with a green purification process and no chemical residues. 260000 mcg high content, 80 capsules per bottle, one bottle can be taken for 2-3 months. 10 times effective absorption, clinical validation for 72 hours to promote improvement in physical indicators and compensate for the blind spots in ordinary NMN repair. International authoritative certification, guaranteed authenticity, FDA certification, SGS certification, GMP certification, COO certification, and certificate of origin in the United States.

China NMN (GSHWORLD) adopts a highly difficult fermentation and biological enzyme method, which mimics the working process of catalytic enzymes in the human body to produce NMN. It is green and optimized, but the process is complex, time-consuming and labor-intensive, and the output is relatively small. Most ordinary MNMs are chemical extraction processes, which are commonly used and indeed reduce costs. However, it is difficult to avoid chemical residues, which will increase the complexity of the formation during the conversion of NAD+, Reduce the effectiveness of use. Long term accumulation of chemical residues can also bring many uncertain health risks.

8、 How does the body manufacture nicotinamide adenine dinucleotide (NAD+)?

Our body naturally produces NAD+from smaller components or precursors. Treat them as raw materials for NAD+. There are five main precursors in the human body: tryptophan, nicotinamide (Nam), niacin (NA or niacin), nicotinamide nucleoside (NR), and nicotinamide mononucleotide (NMN). Among them, NMN is the final step in NAD+synthesis.

These precursors can all come from diet. Nam, NA, and NR are all important nutrients for vitamin B3. Once inside the human body, our cells can synthesize NAD+through several different pathways. A biochemical pathway is equivalent to a factory production line. In the case of NAD+, multiple production lines lead to the same product.

The first of these pathways is called the ab initio pathway. De novo is a Latin expression that is equivalent to “starting from scratch.” The precursor of NAD+, tryptophan, starts from scratch and is established from there upwards.

The second approach is called a rescue approach. The recycling pathway is similar to recycling, as it produces NAD+from the products of NAD+degradation. All proteins in the body need to be regularly degraded to prevent them from accumulating to unhealthy levels. As part of the production and degradation cycle, enzymes place some of the results of protein degradation back into the same protein production line.

NAD+NMN biosynthesis

9、 How is NMN synthesized in the body?

NMN is produced by the B vitamins in the body. The enzyme responsible for producing NMN in the body is called nicotinamide phosphoribosyltransferase (NAMPT). NAMPT attaches nicotinamide (vitamin B 3) to a phosphate sugar called PRPP (5 ‘- phosphoribosyl-1-pyrophosphate). NMN can also be composed of ‘nicotinamide nucleoside’ (NR) by adding a phosphate group.

NAMPT is a rate limiting enzyme produced by NAD+. This means that low levels of NAMPT lead to a decrease in NMN production, resulting in a decrease in NAD+levels. Adding precursor molecules like NMN can also accelerate the production of NAD+.

Methods to improve NAD+levels

Fasting or reducing calorie intake, better known as calorie restriction, has been shown to increase NAD+levels and sirtuin activity. In mice, increasing NAD+and sirtuin activity through calorie restriction has been shown to slow down the aging process. Although NAD+exists in some foods, its concentration is too low, which affects intracellular concentration. Taking certain supplements, such as Chinese NMN (GSHWORLD), has been shown to increase NAD+levels.

10、 How are NMN supplements absorbed and distributed throughout the body?

NMN seems to be absorbed into cells through molecular transport and embedded on the cell surface. Due to the smaller size of NMN molecules compared to NAD+, they may be more effectively absorbed by cells. NAD+cannot easily enter the human body due to the barrier of the cell membrane. The membrane has an anhydrous space that prevents ions, polar molecules, and macromolecules from entering without the use of transport proteins. Some people once believed that NMN must change before entering cells, but new evidence suggests that it can enter cells directly through NMN specific transport proteins on the cell membrane.

In addition, injection of NMN leads to an increase in NAD+in many areas of the body, including the pancreas, adipose tissue, heart, skeletal muscles, kidneys, testes, eyes, and blood vessels. Oral administration of NMN in mice can increase liver NAD+within 15 minutes.

Fast conversion from NMN to NAD+