[Daily question] A detailed explanation of the binding mechanism of glutathione (GSH) and GST label protein The specific binding mechanism of glutathione (GSH) to glutathione S-transferase (GST) tag protein involves multiple levels of molecular interactions, and the detailed mechanism is as follows: Structural and functional background Glutathione (GSH) A tripeptide consisting of glutamic acid, cysteine,…
Bilirubin, as a natural product of heme metabolism, has long played an important role in the field of medicine and biomaterials. The traditional extraction method relies on animal bile, which has some problems such as low purity, high cost and ethical controversy. In recent years, the rise of synthetic biology has provided a disruptive solution…
Exploring Cy-Dual probes: An innovative mechanism of glutathione and tyrosinase co-activation in melanoma diagnosis Source journal impact factor and author’s academic background Research background Melanoma is a highly aggressive malignancy with a survival rate of less than 10% in advanced patients, while early diagnosis can significantly improve prognosis through surgery (80% of patients are recurrence-free…
Potential benefits of NMN for hyperlipidemia: Exploring new pathways for cell health Nicotinamide adenine dinucleotide (NAD+) is an important intracellular coenzyme involved in a wide range of key metabolic reactions such as glycolysis, the tricarboxylic acid cycle, fatty acid beta-oxidation and mitochondrial respiration. With age there is a gradual decline in the level of NAD+…
In the vast and sophisticated “universe” of our bodies, there are countless substances that are essential for the activity of life, and glutathione is one of them. It is not only the most common substance in the human body, but also an “invisible guard” that silently guards our health. Glutathione is everywhere Glutathione content in…
Citicoline is a neuroprotective agent Citicoline is one of the common drugs used in the treatment of central nervous system. It is often used in the treatment of cerebral infarction, cerebral insufficiency, cerebral atrophy and other diseases, especially for patients with cerebral infarction. The essence of citicoline is an activator of energy metabolism, which plays…
How about glutathione for melasma? Recently, many friends are asking, can glutathione treat melasma? That’s a good question! As a dermatologist, I’m here to talk about it. Melasma, also known as “butterfly spots”, is a common skin problem that afflicts many women, and asymmetrical yellowish-brown patches on the face are really annoying. Glutathione, also known…
Glutathione (GSH) is a naturally occurring antioxidant produced by the liver and central nervous system that is said to help metabolize toxins, break down free radicals, support immune function, and more. Researchers have explored its potential use for diseases such as cystic fibrosis, chemotherapy-related toxicity, and Parkinson’s disease. There is currently insufficient scientific evidence to…
What are important functions and effects of citicoline? Citicoline, or CDP-choline, is an important biochemical substance. In our bodies, it is widely used to synthesize phospholipids, especially the main components of cell membranes. Citicoline has a wide range of functions, especially in the health of the nervous system and cognitive function plays an important role….
Research points This article investigates the metabolic mechanism of glutathione (GSH) as an antioxidant in Corynebacterium glutamicum, and constructs an efficient glutathione producing strain through metabolic engineering and fermentation optimization strategies. Research has found that by modifying glutathione synthase (GshF), knocking out genes related to hydrogen sulfide production and glutathione degradation, and combining with overexpression…