There are 100 billion nerve cells in the human brain, which begin to gradually decrease by the age of 20. NMN
By the age of 40, 10,000 nerve cells in the brain are lost every day, which is accompanied by memory loss and brain function decline.
A new NMN study on vascular dementia released.
Researchers have discovered a protective measure that may help prevent vascular dementia (VD). Vascular dementia (VD) is the second most common type of dementia after Alzheimer disease and is particularly prevalent in North America and Europe.
In Cellular and Molecular Neurobiology, researchers have discovered a new method that can effectively reduce memory loss in rats with vascular dementia (VD).
They found that the combined effects of NMN and cyticholine reduced inflammation and brain damage, providing greater cognitive protection.
This study reveals that a combination of anti-aging compounds provides better cognitive protection in mice with dementia than when used alone.
We have demonstrated that the combination of cytoline and NMN in vascular dementia [VD] rats can maintain the normal physiological state of neurons, inhibit neuroinflammation in the brain, and ultimately reduce white matter damage in vascular dementia [VD] rats. and cognitive dysfunction.
From the perspective of the mechanism of aging, various aging symptoms that come with age are closely related to the decline in NAD+ levels in the body, and brain health is no exception.
So, does increasing the NAD+ level in the body help the brain fight aging?
Let’s take a look at other past research
NMN can protect cerebral microvessels, ensure the delivery of oxygen and nutrients required by the brain, and discharge of metabolites. Reduce oxidative stress in cerebral microvascular endothelium. Activate SIRT1, increase cerebral blood flow, and improve cognitive abilities. At the same time, it can also prevent memory dysfunction caused by postoperative radiotherapy and chemotherapy and protect nerves.
NMN prevents nervous system aging
The results published by the research team in Nature Communication in March 2022 showed that supplementing NMN activated the expression of SIRT2 and restored myelin regeneration ability, showing the great potential of NMN to prevent the aging of the nervous system.
In 2019, Dr. Tarantini S of the University of Oklahoma Health Science Center and others found that intraperitoneal injection of NMN had a significant protective effect on the brain microvessels of aging mice. NMN could reduce oxidative stress in the brain microvascular endothelium, improve endothelial function, and rescue aging mice. Neurovascular coupling (NVC) responses in mouse cortex, which may contribute to improved cerebral cortical function.
In 2020, research by Dr. Tamas Kiss and others from the University of Oklahoma Health Science Center also found that restoring cellular NAD+ levels in aging mice through intraperitoneal injection of Nicotinamide Mononucleotide can rescue neurovascular function, increase cerebral blood flow, and improve cognitive abilities.
The researchers injected Nicotinamide Mononucleotide intraperitoneally into 24-month-old mice for two consecutive weeks and compared the data with the control group. Of the 590 genes differentially expressed in aged neurovascular units, 204 were restored to young expression levels by NMN.
There are still many trials ongoing, such as the therapeutic effect of NMN on different insomnia patients, the importance of NMN and NAD+ in cardiovascular and neurodegenerative diseases, etc. We believe that it can discover more effects and uses. method.
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As the pioneer of global enzymatic catalytic coupling ATP regeneration technology, it has been authorized 12 Chinese invention patents, 1 utility model patent, 1 international invention patent (authorized by the United States), and 8 software copyrights.
