【 Recommended Synthetic Biological Advantage Products 】 By 2030, the market size can reach 5.1 billion yuan, and the production process technology of high-yield Adenosyl methionine (SAM)
What is S-Adenosyl methionine?
S-adenosyl methionine (SAM) is an important intermediate metabolite that can participate in many biochemical reactions in the body, such as the synthesis of nucleic acids, proteins, phospholipids, and vitamins, as well as the mutual conversion of sulfur-containing compounds such as cysteine, glutathione, polyamines, coenzyme A, and taurine, as methyl donors, alanine donors, and thiol precursor.
SAM also plays a crucial role in the latest mRNA vaccine preparation technology, serving as an important substrate for mRNA stability modification.
SAM action type
SAM, as a precursor of metabolic pathways, has the following functions: methylation, thiolation, and aminopropylation.
transmethylation
SAM plays an important physiological role as the sole methyl donor in intracellular methylation reactions.
SAM methyltransferase can transfer methyl groups from SAM to atoms such as sulfur, nitrogen, and carbon to participate in the synthesis and metabolism of substances in the body. For example, methyltransferase transfers methyl groups from SAM to aminoacetic acid.
After demethylation, SAM generates S-adenosylhomocysteine (SAH), which is a competitive inhibitor of the methylation reaction.
Transsulfurization
The S-Adenosyl homocysteine formed by SAM through methylation is rapidly metabolized into homocysteine in the body.
Cysteine sulfide synthase catalyzes the reaction of homocysteine and serine to produce cysteine sulfide, which is metabolized through a series of processes to produce glutathione (GSH).
Transaminopropyl action
SAM plays an important role in polyamine synthesis. After decarboxylation, SAM generates 5 ‘- adenosylmethylthiamine, which transfers the aminopropyl group in this substance to putrescine, resulting in the production of spermidine and spermine, which are important polyamines in eukaryotes.
After removing the aminopropyl group, 5 ‘- Adenosyl methylthiopropylamine generates 5’ – methylthio Adenosyl, which is rapidly converted into methionine in the body.
Market Size
According to VMR data, the global SAM market size was 3.1 billion RMB (approximately 440 million USD) in 2021, and it is predicted to reach 5.1 billion RMB (730 million USD) by 2030, with a CAGR of 6.2%.
The estimated global consumption in 2021 is 1300 tons.
TECHNICAL INDEX
- Production method: direct fermentation method
- Fermentation yield: 16g/L
- Purity: 98%
GSH BIO-TECH is an innovative high-tech enterprise with the core of enzyme catalysis technology in the field of synthetic biology and the interdisciplinary application of multidisciplinary technology.
The aim is to develop biotechnology and industrialization of high value-added API. The p ioneer of the global enzymatic catalyzed coupled ATP regeneration technology, we advocate green production and has been committed to providing customers with better and more environmentally friendly products and services.
As a powerful production-oriented enterprise, we truly integrate R&D, production and sales, with stable supply and quality for customers and double guarantee of service.
The company’s main products are L-Glutathione Reduced(GSH), β-Nicotinamide Mononucleotide(NMN) , Citicoline Sodium(CDPC) and other raw materials.
The acid market share ranks among the top three in China, and the products are exported to Europe, America, South Korea, India and other parts of the world.
